AI Article Synopsis
- - This study investigates how salivary secretory immunoglobulin A (IgA), an important part of the immune system, changes with age in healthy individuals aged 11 to 70 years old.
- - Researchers collected saliva samples from 120 participants and measured IgA levels using specific testing techniques, finding significant variations across different age groups (with the highest levels at ages 41-60).
- - The findings indicate that salivary IgA decreases in older age, suggesting that strategies like oral immunization could enhance immunity as IgA levels decline throughout life.
Article Abstract
Background: Secretory immunoglobulin A (IgA) is the first line of defense against pathogens that invade mucosal surfaces. It has been reported that the immune system exhibits profound age-related changes. The aim of this study was to investigate the age-dependent changes of salivary IgA among healthy individuals.
Materials And Methods: Saliva samples were collected from 120 healthy individuals (aged 11-70 years). The salivary IgA concentrations were measured by the use of a single radial immunodiffusion technique and analyzed using the Mann-Whitney U, Kruskal-Wallis, and Chi-square tests.
Results: The mean salivary IgA levels were 81.11 ± 4.50 mg/dl at age 11-20 years, 92.71 ± 13.76 mg/dl at age 21-30 years, 96.50 ± 4.04 mg/dl at age 31-40 years, 104.96 ± 10.15 mg/dl at age 41-50 years, 113.22 ± 7.85 mg/dl at age 51-60 years, and 91.38 ± 4.77 mg/dl at age 61-70 years. There was a significant difference among the mean salivary IgA levels of different age groups ( < 0.001).
Conclusion: These results showed that the salivary IgA levels exhibit age-related changes. Oral immunization may be considered to improve oral immunity when the salivary concentrations of IgA begin to decrease during lifetime.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375946 | PMC |
| http://dx.doi.org/10.4103/jpbs.JPBS_605_20 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!