Nonlinear differential equations model diverse phenomena but are notoriously difficult to solve. While there has been extensive previous work on efficient quantum algorithms for linear differential equations, the linearity of quantum mechanics has limited analogous progress for the nonlinear case. Despite this obstacle, we develop a quantum algorithm for dissipative quadratic n-dimensional ordinary differential equations. Assuming [Formula: see text], where R is a parameter characterizing the ratio of the nonlinearity and forcing to the linear dissipation, this algorithm has complexity [Formula: see text], where T is the evolution time, ϵ is the allowed error, and q measures decay of the solution. This is an exponential improvement over the best previous quantum algorithms, whose complexity is exponential in T. While exponential decay precludes efficiency, driven equations can avoid this issue despite the presence of dissipation. Our algorithm uses the method of Carleman linearization, for which we give a convergence theorem. This method maps a system of nonlinear differential equations to an infinite-dimensional system of linear differential equations, which we discretize, truncate, and solve using the forward Euler method and the quantum linear system algorithm. We also provide a lower bound on the worst-case complexity of quantum algorithms for general quadratic differential equations, showing that the problem is intractable for [Formula: see text] Finally, we discuss potential applications, showing that the [Formula: see text] condition can be satisfied in realistic epidemiological models and giving numerical evidence that the method may describe a model of fluid dynamics even for larger values of R.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536387 | PMC |
http://dx.doi.org/10.1073/pnas.2026805118 | DOI Listing |
Eur J Pediatr
March 2025
Department of Pediatrics, CHU de Québec-Université Laval, 2705 Boulevard Laurier, Québec, Québec, G1V 4G2, Canada.
Unlabelled: To explore whether prenatal conditions (i.e. chorioamnionitis, preeclampsia or small-for-gestational age (SGA)) affect the very preterm infant's response to docosahexaenoic acid (DHA) on bronchopulmonary dysplasia (BPD), according to mode of delivery, an independent factor shown to modulate this association.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
March 2025
Tokyo Daigaku, Dept Chem, JAPAN.
We developed a method to reveal the kinetic features of macrocyclization using machine-learning-augmented data. Thirty-six experimental yield datasets were expanded to two hundred datasets through machine learning, enabling kinetic analyses of concentration-dependent yields. This augmented data allowed the chemistry underlying the predictive black box to be elucidated, providing quantitative insights such as rate constants and effective molarity through least-squares fitting of differential rate equations.
View Article and Find Full Text PDFPharm Res
March 2025
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Room 623, HSF2 Building, Baltimore, MD, 21201, USA.
Purpose: There are scarce reports on in vitro-in vivo correlation (IVIVC) model development of immediate-release (IR) formulations, and few investigations of the impacts of formulation and process of spray-dried solid dispersions (SDD)-based tablets on human pharmacokinetics (PK), despite commercial product successes. The goal of this study was to investigate the formulation and process factors that impact bioavailability enhancement of IR itraconazole SDD tablets; and to develop an FDA level A IVIVC that would predict in vivo PK performance from in vitro dissolution testing.
Methods: A direct, differential-equation-based IVIVC model approach was employed, using an oral solution for post-dissolution disposition and Fast-, Medium-, and Slow-release tablets.
Sci Rep
March 2025
Department of Electrical Engineering, Imam Khomeini Naval Science University of Nowshahr, Nowshahr, Iran.
Nerve signal conduction, and particularly in myelinated nerve fibers, is a highly dynamic phenomenon that is affected by various biological and physical factors. The propagation of such moving electric signals may seemingly help elucidate the mechanisms underlying normal and abnormal functioning. This work aims to derive the exact physical wave solutions of the nonlinear partial differential equations with fractional beta-derivatives for the cases of transmission of nerve impulses in coupled nerves.
View Article and Find Full Text PDFSci Rep
March 2025
Department of Mathematics, AIR University, Sector E-9, Islamabad, Pakistan.
Fluids possessing advanced thermal capabilities are a requirement of today's world scientific technology and are an inherent vital part of diversified large-scale processes. As a result, the induction of nanometric-sized particles has been considered an emerging approach to achieve advanced liquids. Various combinations have been used to enhance the efficiency of nanofluids in thermal engineering systems.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!