AI Article Synopsis
- The study focuses on a significant fish pathogen affecting salmonid farming, highlighting the need to understand genetic variations in its virulence.
- Researchers analyzed whole-genome sequences from 25 isolates across Baltic Sea countries and found a consistent population with no clear link between their genetic makeup and virulence traits.
- Further analysis of specific isolates identified genetic differences related to leucine-rich repeat proteins and other elements, offering new insights into how these variations might influence the pathogen's virulence.
Article Abstract
The fish pathogen is currently one of the main pathogenic bacteria hampering the productivity of salmonid farming worldwide. Although putative virulence determinants have been identified, the genetic basis for variation in virulence of is not fully understood. In this study, we analyzed whole-genome sequences of a collection of 25 isolates from Baltic Sea countries and compared genomic information with a previous determination of their virulence in juvenile rainbow trout. The results revealed a conserved population of that were consistently present across the Baltic Sea countries, with no clear association between genomic repertoire, phylogenomic, or gene distribution and virulence traits. However, analysis of the entire genome of four isolates by hybrid assembly provided an unprecedented resolution for discriminating even highly related isolates. The results showed that isolates with different virulence phenotypes harbored genetic variances on a number of consecutive leucine-rich repeat (LRR) proteins, repetitive motifs in gliding motility-associated protein, and the insertion of transposable elements into intergenic and genic regions. Thus, these findings provide novel insights into the genetic variation of these elements and their putative role in the modulation of virulence.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400371 | PMC |
| http://dx.doi.org/10.3390/microorganisms9081658 | DOI Listing |
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