AI Article Synopsis
- * Using a microdissection method, HPV genotypes were identified in 651 cases, revealing specific types like HPV16, 34, and 56 linked to MNC occurrence.
- * Findings suggest that high-risk HPV genotypes, especially HPV16 and 56, may contribute to abnormal cell changes and that the presence of MNCs could indicate potential squamous intraepithelial lesions.
Article Abstract
Many genotypes of human papillomaviruses (HPVs) may lead to morphological changes in cells, resulting in various atypical cells, such as multinucleated cells (MNCs) and koilocytes, in the cervix. However, the relationships between the profiles of HPV genotypes and MNCs are not exactly known. Thus, this study comprehensively profiles the HPV genotypes in MNCs using a microdissection method. HPV genotypes and MNCs were detected in 651 cases with an abnormal Pap smear by liquid-based cytology. Specific HPV genotypes were also detected, including HPV16, 34, and 56, which might be associated with MNCs. This result suggests that the high-risk HPV genotypes, such as HPV16 and 56, are associated with the atypical changes in MNC morphology from normal cervical cells. The results also show that MNCs may be a predictor of squamous intraepithelial lesion.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401768 | PMC |
| http://dx.doi.org/10.3390/microorganisms9081575 | DOI Listing |
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