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Enhanced oral absorption and biodistribution to submandibular salivary glands of D-limonene in Sprague Dawley rats via a liquid-lipid formulation approach.
Int J Pharm
January 2025
UniSA: Clinical & Health Sciences, University of South Australia, Adelaide, Australia. Electronic address:
Decreased saliva production due to salivary gland damage can result in difficulty speaking and swallowing, significantly reducing quality of life for head and neck cancer patients receiving radiotherapy. It is therefore imperative that treatment options are available to mitigate the effects of these debilitating side effects. D-limonene, a naturally occurring terpene, has shown protective effects on saliva production during radiotherapy treatment of mice, however the lipophilic nature of the molecule has necessitated a high oral dose to facilitate sufficient absorption.
View Article and Find Full Text PDFTowards a sustainable model for a digital learning network in support of the Immunization Agenda 2030 -a mixed methods study with a transdisciplinary component.
PLOS Glob Public Health
December 2024
Bridges to Development, Geneva, Switzerland.
The Immunization Agenda 2030 (IA2030) has been endorsed at the World Health Assembly as the world's strategy for immunization. The Movement for IA2030 is a voluntary collective of immunization practitioners, principally from low- and middle-income countries, who have pledged to support each other to accelerate local action in support of this global strategy. Collective action is facilitated by the peer learning platform established by The Geneva Learning Foundation (TGLF).
View Article and Find Full Text PDFClinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations.
Elife
December 2024
Department of Computer Science, University of Oxford, Oxford, United Kingdom.
Sudden death after myocardial infarction (MI) is associated with electrophysiological heterogeneities and ionic current remodelling. Low ejection fraction (EF) is used in risk stratification, but its mechanistic links with pro-arrhythmic heterogeneities are unknown. We aim to provide mechanistic explanations of clinical phenotypes in acute and chronic MI, from ionic current remodelling to ECG and EF, using human electromechanical modelling and simulation to augment experimental and clinical investigations.
View Article and Find Full Text PDFPreliminary Treatment by Exogenous 24-Epibrassinolide Influences Burning-Induced Electrical Signals and Following Photosynthetic Responses in Pea ( L.).
Plants (Basel)
November 2024
Department of Biophysics, N.I. Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, Russia.
Long-distance electrical signals (ESs) are an important mechanism of induction of systemic adaptive changes in plants under local action of stressors. ES-induced changes in photosynthesis and transpiration play a key role in these responses increasing plant tolerance to action of adverse factors. As a result, investigating ways of regulating electrical signaling and ES-induced physiological responses is a perspective problem of plant electrophysiology.
View Article and Find Full Text PDFAn approach based on ecosystem services for assessing progress towards sustainable development goals at both national and provincial levels in China.
Sci Rep
November 2024
College of Architecture and Environment, Sichuan University, Chengdu, 610064, People's Republic of China.
Ecosystem services (ESs), the benefits nature provides to people, are an important basis for fulfilling sustainable development goals (SDGs). Therefore, an ES-based approach will help deepen our understanding of the relationships between natural systems and human well-being and provide co-benefit pathways for sustainable development. However, monitoring progress towards achieving the SDGs based on the contributions of ESs to SDGs is lacking.
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