Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
SSRIs and SNRIs (SRI) in Pregnancy: Effects on the Course of Pregnancy and the Offspring: How Far Are We from Having All the Answers?
Int J Mol Sci
May 2019
Maccabi Institute of Research and Innovation, Tel Aviv University, Tel Aviv, Israel and Ariel University, Ariel 40700, Israel.
Serotonin has important roles in the development of the brain and other organs. Manipulations of synaptic serotonin by drugs such as serotonin reuptake inhibitors (SRI) or serotonin norepinephrine reuptake inhibitors (SNRI) might alter their development and function. Of interest, most studies on the outcome of prenatal exposure to SRI in human have not found significant embryonic or fetal damage, except for a possible, slight increase in cardiac malformations.
View Article and Find Full Text PDFNeuroendocrine and immune disequilibrium as a probable link between metabolic syndrome and carcinogenesis.
Med Hypotheses
September 2018
Division of Endocrinology, Medical Centre of Varna, Varna, Bulgaria. Electronic address:
Numerous investigations prove a higher incidence of carcinogenesis in metabolic syndrome (MetS). They indicate the important role of obesity, elevated inflammatory biomarkers, hyperinsulinemia, hyperglycemia, and dyslipidemia as well. Elevated plasma insulin and free insulin-like growth factor-1 (IGF-1) levels stimulate cell proliferation.
View Article and Find Full Text PDFNivolumab-induced thyroid dysfunction in patients with lung cancer.
Endocrinol Diabetes Nutr (Engl Ed)
January 2019
Department of Endocrinology, Hospital Universitario de la Princesa, Instituto de Investigación Princesa, Universidad Autónoma de Madrid, C/ Diego de León 62, 28006 Madrid, Spain.
Background: Nivolumab is an anti-cancer monoclonal antibody that inhibits PD1 and modulates T-cell response. It has been shown to significantly improve survival in several types of cancer, but clinical trials have also reported an increased risk of developing immune-related adverse events (IRAEs). Endocrine IRAEs may be particularly relevant.
View Article and Find Full Text PDFHair repigmentation associated with the use of lenalidomide: graying may not be an irreversible process!
J Oncol Pharm Pract
June 2013
Department of Hematology-Oncology, St Francis Hospital and Medical Center, Hartford, CT 06105, USA.
We report the first case of progressive hair repigmentation associated with the use of lenalidomide in an elderly patient with multiple myeloma. The influence of lenalidomide on follicular melanogenesis may involve removing the inhibitory influences of some cytokines such as IL-1, IL-6 and TNF-α. In addition, certain endocrine effects of lenalidomide on the hypophyseal-adrenal axis could explain its action on hair pigmentation.
View Article and Find Full Text PDFThe role of the kynurenine metabolism in major depression.
J Neural Transm (Vienna)
February 2012
Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University, Nussbaumstr. 7, 80336, Munich, Germany.
There are circumferential evidences that major depression is associated with mild pro-inflammatory state. Both physiological and psychological stress can induce increased production of pro-inflammatory mediators, reactive oxygen species (ROS) and hypothalamo-hypophyseal-adrenal axis disturbances. While both pro-inflammatory mediators and ROS could activate the tryptophan breakdown and kynurenine pathway with a shift toward the neurotoxic arm, chronic hypercortisolism could also enhance tryptophan breakdown and induce neurodegenerative changes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!