Dementia is a debilitating impairment of cognitive functions that affects millions of people worldwide. There are several diseases belonging to the dementia spectrum, most prominently Alzheimer's disease (AD), vascular dementia (VD), Lewy body dementia (LBD) and frontotemporal dementia (FTD). Repetitive transcranial magnetic stimulation (rTMS) is a safe, non-invasive form of brain stimulation that utilizes a magnetic coil to generate an electrical field and induce numerous changes in the brain. It is considered efficacious for the treatment of various neuropsychiatric disorders. In this paper, we review the available studies involving rTMS in the treatment of these dementia types. The majority of studies have involved AD and shown beneficial effects, either as a standalone, or as an add-on to standard-of-care pharmacological treatment and cognitive training. The dorsolateral prefrontal cortex seems to hold a central position in the applied protocols, but several parameters still need to be defined. In addition, rTMS has shown potential in mild cognitive impairment as well. Regarding the remaining dementias, research is still at preliminary phases, and large, randomized studies are currently lacking.
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http://dx.doi.org/10.3390/healthcare9080949 | DOI Listing |
Alzheimers Dement
December 2024
The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background: The study of the involvement of the cerebellum in learning and memory has become one of the recent hot topics in the field of cognitive neuroscience. Transcranial magnetic stimulation (TMS) of the cerebellum has gained increasing interest in the treatment of cognition-related disorders, making it necessary to determine the optimal parameters for cerebellar TMS. In this study, we aim to explore the effects of different frequencies of cerebellar repetitive TMS (rTMS) on working memory regulation and the associated electrophysiological changes.
View Article and Find Full Text PDFNeurol Sci
January 2025
School of Rehabilitation Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Background: Repetitive transcranial magnetic stimulation (rTMS) has shown potential in alleviating hemiplegic shoulder pain (HSP) and improving upper limb function, yet its efficacy remains debated. This study aims to assess the effectiveness of rTMS for HSP through a systematic review and meta-analysis.
Methods: Four databases were searched with the keywords "rTMS" and "HSP".
Front Psychol
December 2024
Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Centre de Recherche en Neurosciences de Lyon U1028 UMR5292, PSYR2, Bron, France.
Background: Anhedonia, including social, physical, and less-known, olfactory, stands as a core symptom of major depressive disorder (MDD). At the neurobiological level, anhedonia has been associated with abnormal activity within the reward system, suggesting a key role for dopamine. Repetitive Transcranial Magnetic Stimulation (rTMS) has emerged as an innovative treatment for alleviating depressive symptoms.
View Article and Find Full Text PDFArch Phys Med Rehabil
December 2024
Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China; Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China; Clinical Research Center for Precision Diagnosis and Treatment of Neurological Diseases of Fujian Province, Fuzhou, China. Electronic address:
Objective: Repetitive transcranial magnetic stimulation (rTMS) is a promising approach in improving swallowing function after stroke. However, comparative efficacy of different rTMS protocols for post-stroke dysphagia (PSD) remains unclear.
Data Sources: PubMed, Embase and Cochrane database were systematically searched for eligible random controlled trials (RCTs) from inception to 30 August 2024.
Psychiatry Res
December 2024
Eating Disorders Unit, Department of Neuroscience "Rita Levi Montalcini", University of Turin, via Cherasco 15, 10126, Turin, Italy. Electronic address:
Background: Psychosocial and pharmacological interventions can effectively treat eating disorders (EDs), but improvements are often short-term and modest. Neuromodulation, altering nerve activity through targeted neurological stimulation, is an emerging intervention in neuropsychiatric disorders. This meta-review synthesizes evidence on neuromodulatory techniques in ED patients, identifying research gaps and future directions.
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