[Prazosin pharmacodynamics and pharmacokinetics in patients with myocardial infarct complicated by heart failure in the subacute period].

Central hemodynamic parameters were monitored by invasive procedures (pulmonary arterial catheterization), and prazosin kinetics following the administration of a single 5 mg dose were determined in 69 patients with subacute myocardial infarction, complicated by heart failure. The response to prazosin was dependent on pretreatment hemodynamic parameters and differed between patients with early and manifest heart failure. There was a correlation between the peaks of hemodynamic change and drug concentration.