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InterDIA: Interpretable Prediction of Drug-induced Autoimmunity through Ensemble Machine Learning Approaches.
Toxicology
January 2025
Deparment of clinical pharmacy, Jieyang People's Hospital, 522000, China. Electronic address:
Drug-induced autoimmunity (DIA) is a non-IgE immune-related adverse drug reaction that poses substantial challenges in predictive toxicology due to its idiosyncratic nature, complex pathogenesis, and diverse clinical manifestations. To address these challenges, we developed InterDIA, an interpretable machine learning framework for predicting DIA toxicity based on molecular physicochemical properties. Multi-strategy feature selection and advanced ensemble resampling approaches were integrated to enhance prediction accuracy and overcome data imbalance.
View Article and Find Full Text PDFGreen building development utilising modified fired clay bricks and eggshell waste.
Sci Rep
January 2025
PV Unit, Solar and Space Research Department, National Research Institute of Astronomy and Geophysics (NRIAG), Helwan, Cairo, Egypt.
The inadequate thermal insulation of the building envelope contributes significantly to the high power consumption of air conditioners in houses. A crucial factor in raising a building's energy efficiency involves utilizing bricks with high thermal resistance. This issue is accompanied by another critical challenge: recycling and disposing of waste in a way that is both economically and environmentally beneficial, including using it to fuel industrial growth, in order to reduce the harmful effects of waste on the environment as waste generation in our societies grows.
View Article and Find Full Text PDFSynthesis and Characterization of Lipid-Polyzwitterion Diblock Copolymers for Optimizing Micelle Formation to Enhance Anticancer Drug Delivery in 2D and 3D Cell Cultures.
Biomacromolecules
January 2025
Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, 15 Kent Ridge Crescent, Singapore 119276, Singapore.
Amphiphilic polymers with distinct polarity differences, known as sharp polarity contrast polymers (SPCPs), have gained much attention for their ability to form micelles with low critical micelle concentrations (CMCs) and potential in anticancer drug delivery. This study addresses the limited research on structure-property relationships of SPCPs by developing various SPCPs and exploring their physicochemical properties and biological applications. Specifically, the superhydrophobic aliphatic palmitoyl (Pal) was coupled to the superhydrophilic zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC) to form Pal-pMPC diblock copolymers.
View Article and Find Full Text PDFConstruction of W/O/W microcapsules based on the combination of polyglycerol polyricinoleate/protein for the co-encapsulation of crocin and quercetin: Physical properties, stability and in vitro digestion.
Food Chem
January 2025
State Key Laboratory of Food Science and Resources, Nanchang University, 235 Nanjing East Road, Nanchang, Jiangxi 330047, China.
Due to health reasons of polyglycerol polyricinoleate (PGPR), there has been a growing interest in reducing it. To address this, this study developed the PGPR/Protein (whey, pea, and chickpea protein isolates) emulsifier combinations. The effects of these combinations on the preparation, structure, physicochemical and in vitro digestive properties of W/O/W microcapsules were evaluated.
View Article and Find Full Text PDFInfluence of sterilization and exposure to the Ringer's solution on physicochemical properties of nitrocarburized 316 LVM steel.
Acta Bioeng Biomech
September 2024
Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland.
The aim of the study was to investigate the influence of the nitrocarburizing process carried out in low temperature plasma using the active screen at 440 °C on the structure and physicochemical properties of the 316LVM steel. In the paper, results of micro-structure and phase composition of the layers, roughness, and surface wettability, potentiodynamic pitting corrosion resistance, penetration of ions into the solution as well as biological tests were present. The studies were conducted for the samples of both mechanically polished and nitrocarburized surfaces, after sterilization, and exposure to the Ringer's solution.
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