Mitogenome sequencing provides an understanding of the evolutionary mechanism of mitogenome formation, mechanisms driving plant gene order, genome structure, and migration sequences. Data on the mitochondrial genome for family Convolvulaceae members is lacking. , also known as shankhpushpi, is an important medicinal plant under the family Convolvulaceae, widely used in the Ayurvedic system of medicine. We identified the mitogenome of using the Illumina mate-pair sequencing platform, and annotated using bioinformatics approaches in the present study. The mitogenome of was 344184 bp in length and comprised 46 unique coding genes, including 31 protein-coding genes (PCGs), 12 tRNA genes, and 3 rRNA genes. The secondary structure of tRNAs shows that all the tRNAs can be folded into canonical clover-leaf secondary structures, except three , and . Measurement of the skewness of the nucleotide composition showed that the AT and GC skew is positive, indicating higher A's and G's in the mitogenome of . The Ka/Ks ratios of 11 protein-coding genes (, , , , , , , , , , ) were <1, indicating that these genes were under purifying selection. Synteny and gene order analysis were performed to identify homologous genes among the related species. Synteny blocks representing nine genes (, , , , , , , , nad7) were observed in all the species of . Gene order comparison showed that a high level of gene rearrangement has occurred among all the species of . The mitogenome data obtained in the present study could be used as the family representative for future studies, as there is no complex taxonomic history associated with this plant.
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http://dx.doi.org/10.3390/life11080769 | DOI Listing |
Sci Rep
January 2025
Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.
Malaria has been a leading cause of death in human populations for centuries and remains a major public health challenge in African countries, especially affecting children. Among the five Plasmodium species infecting humans, Plasmodium falciparum is the most lethal. Ancient DNA research has provided key insights into the origins, evolution, and virulence of pathogens that affect humans.
View Article and Find Full Text PDFParasitol Int
January 2025
Departamento de Biologia Animal, Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, BR-465 km 7, 23897-000 Seropédica, Rio de Janeiro, Brazil.
Black-goggled tanagers Trichothraupis melanops (Vieillot, 1818) are passerine birds commonly observed in the Brazilian Atlantic Forest, Argentina and Paraguay. Tanagers are among the passerines with the highest prevalence and density of coccidian parasites, mainly due to their frugivorous feeding habits that favor fecal-oral transmission. In this context, the current study identifies a new species of Isospora Schneider, 1881 parasitizing black-goggled tanagers captured in the Itatiaia National Park, a protected area with a high degree of vulnerability in Southeastern Brazil.
View Article and Find Full Text PDFCancer Genet
December 2024
Department of Obstetrics and Gynecology, Shanghai Tongji Hospital, School of Medicine, Tongji University, 200120, PR China; Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200065, PR China. Electronic address:
Background: Mitochondrial dysregulation contributes to the chemoresistance of multiple cancer types. Yet, the functions of mitochondrial dysregulation in Ovarian serous cystadenocarcinoma (OSC) remain largely unknown.
Aim: We sought to investigate the function of mitochondrial dysregulation in OSC from the bioinformatics perspective.
Alzheimers Res Ther
January 2025
Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou, Taipei, 112304, Taiwan.
Background: Effective treatment for Alzheimer's disease (AD) remains an unmet need. Thus, identifying patients with mild cognitive impairment (MCI) who are at high-risk of progressing to AD is crucial for early intervention.
Methods: Blood-based transcriptomics analyses were performed using a longitudinal study cohort to compare progressive MCI (P-MCI, n = 28), stable MCI (S-MCI, n = 39), and AD patients (n = 49).
BMC Plant Biol
January 2025
Institute of Tropical Horticulture Research, Hainan Academy of Agricultural Sciences, Haikou, 571100, China.
Background: Tea-oil Camellia within the genus Camellia is renowned for its premium Camellia oil, often described as "Oriental olive oil". So far, only one partial mitochondrial genomes of Tea-oil Camellia have been published (no main Tea-oil Camellia cultivars), and comparative mitochondrial genomic studies of Camellia remain limited.
Results: In this study, we first reconstructed the entire mitochondrial genome of C.
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