Introduction: Aim of this study is to analyse the characteristics of ventilator-associated pneumonia (VAP) inpatients infected by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2).
Materials And Methods: A retrospective study was conducted, including coronavirus infectious disease 2019 (COVID-19) patients who developed VAP from March to May 2020 (VAP COVID-19). They were compared to non-COVID-19 patients who developed VAP from January 2011 to December 2019 (VAP NO COVID-19) and COVID-19 patients who did not develop VAP (NO VAP COVID-19).
Results: Overall, 42 patients were included in the VAP COVID-19group, 37 in the NO VAP COVID-19 group, and 188 in the VAP NO COVID-19 group. VAP COVID-19 had significantly higher rates of shock (71% vs. 48%, = 0.009), death in ICU (52% vs. 30%, = 0.011), VAP recurrence (28% vs. 4%, < 0.0001), positive blood culture (26% vs. 13%, = 0.038), and polymicrobial culture (28% vs. 13%, = 0.011) than VAP NO COVID-19. At the multivariate analysis, death in patients with VAP was associated with shock ( = 0.032) and SARS-CoV-2 ( = 0.008) infection.
Conclusions: VAP in COVID-19 patients is associated with shock, bloodstream, and polymicrobial infections.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388913 | PMC |
| http://dx.doi.org/10.3390/antibiotics10080988 | DOI Listing |
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