AI Article Synopsis
- Humans have a variety of microbes in their intestines that often work symbiotically, but some can contribute to liver diseases.
- The intestinal virome, which includes bacteriophages and eukaryotic viruses, is less understood in the context of liver disease despite being more abundant than bacteria.
- Phages may be used to target harmful bacteria related to liver diseases, and this text will discuss changes in the virome linked to fatty liver disease and cirrhosis, as well as the therapeutic potential and challenges of using phages in treatment.
Article Abstract
Humans harbour a large quantity of microbes in the intestinal tract and have evolved symbiotic relationships with many of them. However, several specific bacterial pathobionts are associated with liver disease pathogenesis. Although bacteriophages (phages) and eukaryotic viruses (collectively known as "the virome") outnumber bacteria and fungi in the intestine, little is known about the intestinal virome in patients with liver disease. As natural predators of bacteria, phages can precisely edit the bacterial microbiota. Hence, there is interest in using them to target bacterial pathobionts in several diseases, including those of the liver. Herein, we will summarise changes in the faecal virome associated with fatty liver diseases and cirrhosis, and describe the therapeutic potential of phages and potential challenges to their clinical application.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929164 | PMC |
| http://dx.doi.org/10.1016/j.jhep.2021.08.003 | DOI Listing |
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