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Background: Reducing risk of dementia requires a person to have accessible information about health and risk factors, person-centered health goals, and self-efficacy. Here, we test the feasibility of a new risk reduction program called Brain Wellness Information, Support, and Empowerment (Brain-WISE). Its unique features are that it (1) is aligned with a theoretical model of behavior change, (2) is relatively brief (six 90-min sessions), (3) is conducted with groups of people who have pre-existing community; (4) includes individual and group activities and person-centered health goals; and (5) is conducted with speech-language therapists.
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Alzheimers Dement
December 2024
Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Background: Currently, most clinical services focus on dementia diagnosis rather than prevention, despite evidence showing benefits of preventative interventions. People often present with memory problems before having dementia, or when in the early stages and are motivated to adopt preventive lifestyle strategies to slow decline. To address gaps in clinical services we set up the Bristol Brain Health Clinic (BHC) in 2017.
View Article and Find Full Text PDFDementia Care Practice.
Alzheimers Dement
December 2024
Mercer's Institute for Successful Ageing, St James's Hospital, Dublin, Ireland.
The World Health Organization (WHO) emphasizes the need to provide support to caregivers of people living with dementia, as one of seven action areas. This is especially crucial in Ghana, where, similar to other Lower Middle-Income Countries (LMICs), the majority of people with dementia reside in the community and are cared for by informal caregivers, often family members. These caregivers usually do not have any training in dementia care and may have limited understanding of the disease and its potential symptoms.
View Article and Find Full Text PDFMethylenetetrahydrofolate reductase mutations refer to genetic variations in the methylenetetrahydrofolate reductase enzyme, which plays an important role in folate metabolism. Folate is essential for neural development and signalling. Children with autism spectrum disorder have atypical neural signals compared with control.
View Article and Find Full Text PDFSOCS1: A potential diagnostic and prognostic marker for aggressive gliomas and a new target for immunotherapy.
Medicine (Baltimore)
December 2024
The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.
Gliomas, the most common and deadly cancers of the central nervous system, present a unique immunological barrier that severely undermines the effectiveness of immunotherapies. Suppressor of cytokine signaling 1 (SOCS1), belonging to the SOCS protein family and playing a pivotal role in various cancer treatment strategies and is abundant in high-grade gliomas. This study conducted a comparative analysis of SOCS1 and glioma immune checkpoints.
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