Hypoglycemia during treatment with the ketogenic diet in a child with refractory epilepsy-results of continuous glucose monitoring.

Neuro Endocrinol Lett

Department of Internal Medicine, Second Faculty of Medicine, v Úvalu 84, 15000 Prague 5, Czech Republic.

Published: August 2021

AI Article Synopsis

  • The ketogenic diet (KD) is an effective treatment for difficult-to-treat epilepsy in children, but it can cause hypoglycemia, especially during the initial phase.
  • Continuous glucose monitoring in a 6-year-old child on KD for over 8 months showed long periods of low blood sugar levels, with significant time spent under critical thresholds.
  • Increasing the carbohydrate intake in the KD led to notable improvements in blood sugar levels.

Article Abstract

The ketogenic diet (KD) is an effective treatment for intractable epilepsy in children. Hypoglycemia can be one of its side-effects, which is considered to be present mainly during the introductory phase of KD. Continuous glucose monitoring in a 6-year old non-diabetic child treated with KD for more than 8 months revealed long periods of asymptomatic hypoglycemia (8.9% of the total time under 2.5 mmol/l, 10.6% of the total time in the range between 2.5-3.0, 29.1% in the range of 3.0-3.6 mmol/l). The episodes of serious hypoglycemia were associated with a fasting state. The amount of sacharides in KD was increased with substantial glycemic profile improvement.

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