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Reflections on the 2024 Final Rule on Public Health Service Policies on Research Misconduct.
Account Res
January 2025
Department of Philosophy, Georgetown University, Washington, USA.
Background: The Office of Research Integrity (ORI) of the U.S. Department of Health and Human Services (HHS) recently issued the 2024 Final Rule on Public Health Service Policies on Research Misconduct (42 CFR 93), the first major revision of the regulation in nearly twenty years.
View Article and Find Full Text PDFNeoadjuvant or perioperative immunotherapy for resectable melanoma: The need for biomarkers.
Eur J Cancer
January 2025
National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark. Electronic address:
Groundbreaking studies have reshaped the treatment landscape for patients with resectable stage ≥IIIB melanoma by demonstrating the benefits of neoadjuvant therapy. Data from the NADINA and SWOG S1801 trials reveal substantial improvements in event-free survival compared to adjuvant therapy alone. These studies employed distinct neoadjuvant immunotherapy approaches - ipilimumab plus nivolumab in NADINA and anti-PD-1 monotherapy in SWOG S1801 - highlighting potential differences in efficacy and toxicity.
View Article and Find Full Text PDFStandardization for Data Generation and Collection in the Dairy Industry: Addressing Challenges and Charting a Path Forward.
Animals (Basel)
January 2025
Zinpro Corporation, Eden-Prairie, MN 55344, USA.
Standards for data generation and collection are important for integration and for achieving data-driven actionable insights in dairy farming. Data integration and analysis are critical for advancing the dairy industry, enabling better decision-making, and improving operational efficiencies. This commentary paper discusses the challenges of and proposes pathways for standardizing data generation and collection based on insights from a multidisciplinary group of stakeholders.
View Article and Find Full Text PDFInvisible Monitoring for Athlete Health and Performance: A Call for a Better Conceptualization and Practical Recommendations.
Int J Sports Physiol Perform
January 2025
Department of Sport and Physical Activity, Faculty of Arts and Sciences, Edge Hill University, Ormskirk, United Kingdom.
Background: Practices to routinely monitor athletes are rapidly changing. With the concurrent exponential rise in wearable technologies and advanced data analysis, tracking training exposures and responses is widespread and more frequent in the athlete-coach decision-making process. Within this scenario, the concept of invisible monitoring emerged, which was initially vaguely defined as testing athletes without testing them.
View Article and Find Full Text PDFPredictive signatures of immune response to vaccination and implications of the immune setpoint remodeling.
mSphere
January 2025
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
In 2020, I featured two articles in the "mSphere of Influence" commentary series that had profound implications for the field of immunology and helped shape my research perspective. These articles were "Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses" by Tsang et al. (Cell 157:499-513, 2014, https://doi.
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