The prevalence of obesity is rapidly increasing and is recognized as a serious health problem. To investigate metabolic changes in an obese model after administration of , mice were divided into four groups: normal diet, high-fat diet (HFD), HFD with treatment fenofibrate, and fruit extract. The liver tissue of mice was analyzed using nuclear magnetic resonance (NMR) spectrometry-based metabolomics. In multivariate statistical analyses, the HFD group was discriminated from the normal diet group, and the group fed fruit was discriminated from the HFD group. In biomarker analysis between the HFD group and the group fed fruit, alanine, inosine, formate, pyroglutamate, taurine, and tyrosine, with AUC values of 0.7 or more, were found. The levels of these metabolites were distinguished from the HFD mouse model. Changes in these metabolites were confirmed to act on metabolic pathways related to antioxidant activity.
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| http://dx.doi.org/10.3390/metabo11080505 | DOI Listing |
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