Bioassay-guided partition of the extract of the Red Sea sponge and HPLC purification of the active fraction gave a psammaplysin dimer, psammaceratin A (), along with psammaplysin A (). The dimer comprises two units of psammaplysin A () connected via the terminal amines with an unprecedented (2,3)-2,3-bis(aminomethylene)succinamide moiety, and it represents the first dimer to be identified among the psammaplysin family. Data from 1D- and 2D-NMR and HRMS supported the chemical structures of the compounds. Psammaceratin A () and psammaplysin A () exhibited significant growth inhibition of HCT 116, HeLa, and MBA-MB-231 cells down to 3.1 μM.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399316 | PMC |
| http://dx.doi.org/10.3390/md19080433 | DOI Listing |
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Psammaceratin A: A Cytotoxic Psammaplysin Dimer Featuring an Unprecedented (2Z,3Z)-2,3-Bis(aminomethylene)succinamide Backbone from the Red Sea Sponge .
Mar Drugs
July 2021
Natural Products Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Bioassay-guided partition of the extract of the Red Sea sponge and HPLC purification of the active fraction gave a psammaplysin dimer, psammaceratin A (), along with psammaplysin A (). The dimer comprises two units of psammaplysin A () connected via the terminal amines with an unprecedented (2,3)-2,3-bis(aminomethylene)succinamide moiety, and it represents the first dimer to be identified among the psammaplysin family. Data from 1D- and 2D-NMR and HRMS supported the chemical structures of the compounds.
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