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Fractional exhaled nitric oxide (FeNO) in students in Northern Thailand: associations with respiratory symptoms, diagnosed allergy and the home environment. | LitMetric

AI Article Synopsis

  • The study investigates the levels of fractional exhaled nitric oxide (FeNO) among first-grade junior high students in northern Thailand, focusing on its relationship with respiratory symptoms and allergies.
  • Findings show that 29.6% of students had elevated FeNO levels, with links found between higher FeNO and diagnosed allergies (especially to cats and dust mites), as well as respiratory symptoms.
  • Environmental factors like indoor mold and gas cooking were associated with lower FeNO levels, highlighting their potential protective role against airway inflammation in children.

Article Abstract

Objective: There are few studies on fractional exhaled nitric oxide (FeNO) among children in subtropical areas. We studied associations between FeNO and respiratory symptoms, reported diagnosed allergies and indoor and outdoor environmental factors in first grade junior high school students ( = 270) in upper northern Thailand.

Methods: Data on demographics, health and home environment were collected by a questionnaire distributed in dry season (February-March 2018). FeNO was measured when the research team visited the school. Daily outdoor pollution data (PM and ozone) were collected from the nearest monitoring station 3 days (lag 3) and 7 days (lag 7) before the FeNO measurements. Two-level (student, school) linear mixed models were used to analyze associations, adjusting for gender and family education level.

Results: In total, 29.6% had elevated FeNO level (>20 ppb) and 7.8% reported any allergy diagnosed by a doctor. Male gender ( = 0.02), diagnosed allergy ( = 0.001), especially to cat ( = 0.001) and house dust mite (HDM) allergies ( = 0.001) were associated with FeNO. Eye symptoms ( = 0.01), rhinitis symptoms ( = 0.03) and dyspnea ( = 0.05) in the last 3 days were associated with FeNO. Household indoor mold ( = 0.03), gas cooking ( = 0.03) and PM (lag 3 and lag 7) were negatively (protective) associated with FeNO.

Conclusions: Diagnosed allergy, especially to cat and HDM, can be associated with increased FeNO. Indoor mold and gas cooking can be associated with lower FeNO. Ocular, nasal and dyspnea symptoms reported by students in dry season in northern Thailand can be associated with FeNO, a biomarker of Th2 driven airway inflammation.

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Source
http://dx.doi.org/10.1080/02770903.2021.1968424DOI Listing

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