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http://dx.doi.org/10.22603/ssrr.2020-0099 | DOI Listing |
J Environ Manage
December 2024
College of Life Science, Hebei University, Baoding, 071002, China; Engineering Research Center of Ecological Safety and Conservation in Beijing-Tianjin-Hebei (Xiong'an New Area) of MOE, Baoding, 071002, China. Electronic address:
Global climate change and extensive human activities are causing rapid transformations in natural ecosystems, leading to the rapid loss of suitable habitats for wildlife, which urgently requires measures to protect global biodiversity. In the past decade, China has invested heavily in ecological restoration, but current projects often do not prioritize biodiversity conservation. Therefore, developing systematic conservation strategies and using quantitative methods to identify conservation key areas and key species within a regional scale is of great importance for current ecological restoration.
View Article and Find Full Text PDFSci China Life Sci
December 2024
State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Salivary proteins serve multifaceted roles in maintaining oral health and hold significant potential for diagnosing and monitoring diseases due to the non-invasive nature of saliva sampling. However, the clinical utility of current saliva biomarker studies is limited by the lack of reference intervals (RIs) to correctly interpret the testing result. Here, we developed a rapid and robust saliva proteome profiling workflow, obtaining coverage of >1,200 proteins from a 50-µL unstimulated salivary flow with 30 min gradients.
View Article and Find Full Text PDFJ Neuroinflammation
December 2024
Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
The immune system has garnered attention due to its association with disease progression in amyotrophic lateral sclerosis (ALS). However, the role of peripheral immune cells in this context remains controversial. Here, we conducted single-cell RNA-sequencing of peripheral blood mononuclear cells to comprehensively profile immune cells concerning the rate of disease progression in patients with ALS.
View Article and Find Full Text PDFOrphanet J Rare Dis
December 2024
Post Graduate School in Allergology and Internal Medicine "Guido Baccelli", Department of Precision and Regenerative Medicine and Ionian Area-(DiMePRe-J), School of Medicine, Aldo Moro University of Bari, Bari, 70124, Italy.
Background: Mucopolysaccharidosis (MPS) type 1 S and type 2 are rare lysosomal storage disorders characterized by impaired enzyme production, resulting in glycosaminoglycans accumulation within lysosomes. Enzyme Replacement Therapy (ERT) with laronidase and idursulfase are first line treatments, respectively. However, infusion-related hypersensitivity reactions (HR) may lead to ERT discontinuation.
View Article and Find Full Text PDFSci Rep
December 2024
School of Resources & Safety Engineering, Central South University, Changsha, 410083, Hunan, China.
To explore the mechanism of water inrush from the mine roof strata, a series of seepage-acoustic emission (SAE) experiments on red sandstone disc samples were carried out. The effects of the height to diameter ratio (H/D) and pore pressure on the mechanical, hydraulic and crack propagation properties of red sandstones were investigated. Test results show that, the peak load of rock samples declines with the decreasing H/D and increasing pore pressure.
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