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The effect of Torque Teno Virus (TTV) Infection on Clinical Outcomes, Genomic Integrity, and Mortality in COPD Patients.
Mech Ageing Dev
January 2025
San Raffaele University; Department of Human Sciences and Promotion of the Quality of Life, Via di Val Cannuta 247, 00166 Rome, Italy; Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Via di Val Cannuta 247, 00166 Rome, Italy. Electronic address:
Introduction: Torque Teno Virus (TTV), an "orphan" virus with unclear pathology, has been associated with various diseases and immune dysfunctions. This study investigates the link between TTV viremia and clinical markers in patients with severe to very severe COPD undergoing respiratory rehabilitation.
Methods: We analyzed 102 elderly COPD patients, stratified by TTV viremia levels (< or ≥ 4 log10 copies/mL).
Viral Metagenomics in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation (HSCT): A Brazilian Experience.
Microorganisms
December 2024
Center for Viral Surveillance and Serological Evaluation (CeVIVAs), Butantan Institute, São Paulo 05585-000, SP, Brazil.
Viral infections are one of the most important causes of morbidity and mortality among patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Immunosuppression may lead to the reactivation of latent viruses or the acquisition of new infections, resulting in severe clinical outcomes. The early detection of viral reactivations is crucial for effective patient management and post-transplant care.
View Article and Find Full Text PDFAnelloviruses and Cancer.
J Infect Dis
December 2024
San Diego Supercomputer Center, University of California, San Diego, California, USA.
Anelloviruses are among the most prevalent viruses within the human virome, detected in over 90% of healthy individuals. Despite their ubiquity, the role of anelloviruses in human health remains elusive. This review examines the potential associations of anelloviruses torque teno virus (TTV), torque teno midi virus (TTMDV), and torque teno mini virus (TTMV) with various cancers, highlighting the mixed conclusions from current epidemiological studies.
View Article and Find Full Text PDFImpact of induction agents and maintenance immunosuppression on torque teno virus loads and year-one complications after kidney transplantation.
Front Immunol
November 2024
Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany.
Article Synopsis
- Torque teno virus load (TTVL) is being studied as a way to measure immune health in kidney transplant patients, particularly how different medications affect TTVL levels.
- In a study of 134 patients, TTVL levels peaked at 90 days post-transplant and were significantly higher in those who received anti-thymocyte globulin (ATG) compared to interleukin-2 receptor antagonists (IL2-RA).
- Higher TTVL levels may indicate a greater risk of infections for patients, though this trend wasn't statistically significant, suggesting that monitoring TTVL could help manage immunosuppressive therapy post-transplant.
Clinical detection of four emerging canine diarrhea-associated viruses and evolutionary analysis of canine kobuvirus.
Arch Virol
November 2024
College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, P.R. China.
In this study, a multiplex PCR method was developed for the detection of four diarrhea-associated viruses of canines, including canine bocavirus (CBoV), canine circovirus (CCV), torque teno canis virus (TTCV), and canine kobuvirus (CKV). Four pairs of compatible primers, one specific for each virus, were designed based on conserved sequences. After optimization of parameters such as primer concentration and annealing temperature in single and multiple amplifications, four specific fragments were amplified simultaneously with high sensitivity and specificity in one PCR reaction.
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