Loss of pressure-induced vasoconstriction increases susceptibility to renal and cerebral vascular injury. Favored paradigms underlying initiation of the response include transient receptor potential channels coupled to G protein-coupled receptors or integrins as transducers. Degenerin channels may also mediate the response. This review addresses the ) evolutionary role of these molecules in mechanosensing, ) limitations to identifying mechanosensitive molecules, and ) paradigm shifting molecular model for a VSMC mechanosensor.
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| http://dx.doi.org/10.1152/physiol.00008.2021 | DOI Listing |
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