Purpose: To report a case of aggressive chorioretinal paracoccidioidomycosis requiring treatment with systemic antifungal agents, frequent intravitreal voriconazole injections, and surgical excision.
Observations: A Brazilian man in his mid-30s with a history of chronic, biopsy-proven cutaneous paracoccidioidomycosis, chronic sinusitis, and perichondritis secondary to paracoccidioidomycosis presented with profound vision loss. He was found to have significant vitreous inflammation and a large chorioretinal lesion in the posterior pole concerning for ocular involvement. He was treated initially with combined topical and systemic steroids as well as systemic antifungals and antibiotics, then with serial intravitreal voriconazole injections resulting in a significant reduction of intraocular inflammation and subretinal fluid. The residual tractional retinal detachment from the chorioretinal lesion was addressed surgically by pars plana vitrectomy.
Conclusion And Importance: Intravitreal voriconazole can be an effective adjuvant treatment for the vitreous inflammation and subretinal fluid associated with chorioretinal paracoccidioidomycosis. Surgical intervention may be indicated in cases complicated by tractional retinal detachment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368784 | PMC |
| http://dx.doi.org/10.1016/j.ajoc.2021.101187 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Case report: Unveiling the silent threat in the ICU - a case of disseminated invasive aspergillosis in a patient with fulminant myocarditis.
Front Immunol
December 2024
Fourth Department of Critical Care Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China.
Invasive aspergillosis (IA) significantly increases mortality in critically ill patients in the ICU and its occurrence is closely related to immunocompromise. Dissemination of IA is easily misdiagnosed and mistreated due to its ability to invade multiple systems throughout the body and lack of typical clinical manifestations. In this case, a 25-year-old previously healthy woman was hospitalized with fulminant myocarditis and treated with veno-arterial extracorporeal membrane pulmonary oxygenation (VA-ECMO) support and intravenous acyclovir, high-dose methylprednisolone, and immunoglobulin.
View Article and Find Full Text PDFProgression of Sclerouveitis to Endogenous Endophthalmitis.
Case Rep Ophthalmol Med
August 2024
Department of Ophthalmology Jones Eye Institute University of Arkansas for Medical Sciences (UAMS), Little Rock, Arkansas, USA.
We describe a unique case of sclerouveitis that progressed to endogenous endophthalmitis in a 69-year-old male with chronic lymphocytic leukemia (CLL). We highlight the risk of treating sclerouveitis with oral corticosteroids, which can exacerbate an infection and contribute to disease progression. A 69-year-old male with CLL on zanubrutinib, a second-generation Bruton's tyrosine kinase inhibitor, was admitted to the hospital for osteomyelitis of the left foot.
View Article and Find Full Text PDFSegmental retinal arteritis in a case of presumed bilateral rifabutin-associated hypopyon uveitis.
Am J Ophthalmol Case Rep
December 2024
Department of Ophthalmology, Medstar Washington Hospital Center/Georgetown University Hospital, 110 Irving St NW, Washington DC, 20010, USA.
Purpose: To describe the presentation and clinical course of bilateral hypopyon uveitis and subsequently diagnosed segmental retinal arteritis in an immunocompromised patient treated with intravitreal and systemic antibiotics while on rifabutin therapy for pulmonary tuberculosis (TB).
Observations: A 63-year-old female from West Africa with a past medical history of HIV/AIDS, hepatitis B, and pulmonary TB presented with pain and acute vision loss in the left eye for two days. She was compliant with her treatment regimen for HIV and maintenance therapy for TB including rifabutin.
Pathobiology of Fungal Endophthalmitis: A Major Review.
ACS Infect Dis
September 2024
Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana 500034, India.
Fungal endophthalmitis is a chronic inflammatory condition of the eye's posterior segment that can lead to irreversible vision loss. While relatively rare in western countries, its incidence is notably higher in Asia, particularly India. The condition's prevalence is exacerbated by factors such as intravenous drug use, antibiotics, and ocular surgeries.
View Article and Find Full Text PDFEndogenous Endophthalmitis after Bone Marrow Transplant: A Case Report and Literature Review.
Vision (Basel)
July 2024
Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.
Purpose: We aim to present a case of disseminated fusariosis that occurred in the setting of immunosuppression and presented with bilateral endogenous endophthalmitis, along with a literature review of endophthalmitis, highlighting management strategies.
Observation: A 70-year-old male with acute myeloid leukemia who had recently undergone a bone marrow transplant noted bilateral floaters and decreased vision. He was found to have bilateral endophthalmitis, with subsequent evidence of fungemia and fusariosis in his skin and joints.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!