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Designing & optimisation of dual Ca and SO ionic cross-linked sericin/pectin microbeads using response surface methodology for colon-specific delivery.
J Biomater Sci Polym Ed
January 2025
School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, India.
Ulcerative colitis, a chronic inflammatory condition of the colon, requires precise and targeted treatment, and polysaccharides, with their pH responsiveness and biodegradability, offer an innovative approach for colon-specific drug delivery. This study aims to develop a highly precise drug delivery system with enhanced therapeutic and targeting efficiency for ulcerative colitis, focusing on the preparation, optimisation, and evaluation of dual cross-linked mesalamine-loaded sericin-pectin (DSPs) micro-beads. These beads utilise the pH-responsive and microflora biodegradability properties of polysaccharides for targeted colon delivery, employing the Response Surface Methodology.
View Article and Find Full Text PDFspores maintain gut homeostasis in murine ulcerative colitis via modulating microbiota, apoptosis, and the TXNIP/NLRP3 inflammasome cascade.
Toxicol Rep
June 2025
Pharmcology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Ulcerative colitis (UC), a persistent immune-mediated disorder lacking effective treatment, is distinguished by gut microbiota dysbiosis, abnormal activation of the NLRP3 inflammasome pathway, and apoptosis. Despite growing attention to these factors, understanding their significance in UC pathogenesis remains a challenge. The present study explores the potential therapeutic impact of (Bc) spores in a murine UC model induced by drinking 4 % (w/v) dextran sulfate sodium (DSS) in C57BL/6 mice.
View Article and Find Full Text PDFAnnual consumption rate of fish types in Tanzania's Singida municipality during 2022.
Heliyon
January 2025
Department of Geography and Environmental Studies, College of Natural and Applied Sciences, Sokoine University of Agriculture, P. O. Box 3038, Morogoro, Tanzania.
This study assessed the annual fish consumption among the households in Singida Municipality. This was due to the long-time of unsatisfactory pupil performance in joining secondary schools which may be linked to a lack of Long-chain omega-3 polyunsaturated fatty acids. The study used a questionnaire based on a random household consumer survey of 204 households.
View Article and Find Full Text PDFUncovering the Beneficial Role of E7 Exhibiting Antioxidant Activity in Ameliorating DSS-Induced Ulcerative Colitis in a Murine Model.
Foods
January 2025
College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Background: Ulcerative colitis (UC) is a chronic intestinal disease of growing global concern. Bacteria associated with fermented food or probiotics regulate immune and inflammatory responses, playing a key role in intestinal immune homeostasis.
Results: Five probiotics with relatively good antioxidant effects, namely H6, QC9, E7, D1, and Q13, were screened out from 30 strains of probiotics through in vitro antioxidant assays.
Sporotrichoid Nocardiosis in an Immunocompetent Patient: A Case Report.
Cureus
December 2024
Internal Medicine, AdventHealth Orlando, Orlando, USA.
spp. rarely cause infection in humans and are most common in the immunocompromised population. Pulmonary nocardiosis is the most common presentation.
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