D-Allose, a Stereoisomer of D-Glucose, Extends the Lifespan of via Sirtuin and Insulin Signaling.

D-Allose (D-All), C-3 epimer of D-glucose, is a rare sugar known to suppress reactive oxygen species generation and prevent hypertension. We previously reported that D-allulose, a structural isomer of D-All, prolongs the lifespan of the nematode . Thus, D-All was predicted to affect longevity. In this study, we provide the first empirical evidence that D-All extends the lifespan of . Lifespan assays revealed that a lifespan extension was induced by 28 mM D-All. In particular, a lifespan extension of 23.8 % was achieved ( < 0.0001). We further revealed that the effects of D-All on lifespan were dependent on the insulin gene and the longevity gene , indicating a distinct mechanism from those of other hexoses, such as D-allulose, with previously reported antiaging effects.