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Efficacy of Repetitive Transcranial Magnetic Stimulation Combined with Botulinum Toxin Type A for Benign Essential Blepharospasm Patients Accompanied by Anxiety and Depression. | LitMetric

AI Article Synopsis

  • The study aimed to assess how botulinum toxin type A (BTX-A) and repetitive transcranial magnetic stimulation (rTMS) impact motor skills, anxiety, and depression in patients with blepharospasm (BEB).
  • Out of 63 patients, those treated with combined BTX-A and rTMS showed a slightly higher improvement rate and longer relief duration compared to those receiving only BTX-A.
  • The results indicated that while both treatments effectively reduced symptoms, combining rTMS with BTX-A provided better overall outcomes for reducing anxiety and depression in BEB patients.

Article Abstract

Objective: To evaluate the improvement of motor, anxiety, and depression in patients with blepharospasm with the use of botulinum toxin type A (BTX-A) and repetitive transcranial magnetic stimulation (rTMS).

Methods: A total of 63 BEB patients accompanied by anxiety/depression were enrolled, among which 28 patients were treated with the injection of botulinum toxin type A (BTX-A) alone, while 35 patients were treated with BTX-A injection combined with rTMS. All patients were followed up for 6 months, and the overall efficacy was evaluated.

Results: BTX-A alone treatment and combined rTMS treatment could both significantly improve the symptoms of patients, and the effective rate was 92.86% and 94.29%, respectively. The duration of efficacy was significantly longer in the combined rTMS treatment group (16.89±3.39 weeks) than in BTX-A treatment group (13.04±3.48 weeks). After treatment, SDS score of BTX-A treatment group and combined rTMS treatment group was 49.69±7.90 and 49.46±6.73, respectively, and there was no significant difference between the two treatment groups; SAS score of BTX-A treatment group and combined rTMS treatment group was 53.88±7.34 and 48.79±6.62, respectively, and there was significant difference between the two treatment groups.

Conclusion: Compared to BTX-A alone treatment, BTX-A combined with rTMS can effectively improve the effect of BTX-A, prolong the duration of blepharospasm relief, and significantly reduce depression and anxiety in patients with BEB.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380137PMC
http://dx.doi.org/10.2147/NDT.S316163DOI Listing

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