The actual dose received during a computed tomography (CT) examination depends on both the patient size and the radiation output of the scanner. To represent the actual patient morphometry, a new radiation dose metric named size-specific dose estimates (SSDEs) was developed by the American Association of Physicists in Medicine in 2011. The purpose of this article is to review the SSDE concept and the factors influencing it. Moreover, the appropriate methodology of SSDE determination and the application of SSDE as a diagnostic reference-level quantity is critically analyzed based on the data available in the literature. It is expected that this review could potentially increase awareness among CT users of the effective utilization of SSDE as a tool to aid in the optimization of radiation dose in CT.
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http://dx.doi.org/10.1088/1361-6498/ac20b0 | DOI Listing |
J Cachexia Sarcopenia Muscle
February 2025
Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, Missouri, USA.
Background: Adeno-associated virus (AAV) 8 and 9 are in clinical trials for treating neuromuscular diseases such as Duchenne muscular dystrophy (DMD). Muscle consists of myofibres of different types and sizes. However, little is known about the fibre type and fibre size tropism of AAV in large mammals.
View Article and Find Full Text PDFJ Control Release
January 2025
Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Furong Laboratory (Precision Medicine), Changsha 410008, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address:
The immunosuppressive tumor microenvironment (TME) plays a crucial role in the progression and treatment resistance of melanoma. Modulating the TME is thus a key strategy for enhancing therapeutic outcomes. Previousstudies have identified clonidine (CLD), an α2-adrenergic receptor agonist, as a promising agent that enhances T lymphocyte infiltration and reduces myeloid-derived suppressor cells within the TME, thereby promoting antitumor immune responses.
View Article and Find Full Text PDFPhys Med Biol
December 2024
King Abdulaziz City for Science And Technology, The National Center for Applied Physics, Riyadh, Al Riyadh Province, 11442, SAUDI ARABIA.
Effective dose was created as a radiological protection dose quantity linked to risk to enable planning of radiological protection for the control of exposure. Its application and use has evolved from occupational and public exposure during work with radiation sources to medicine and applications in patient dosimetry. Effective dose is the sum of doses to organs and tissues within the body weighted according to their sensitivity to radiation for induction of stochastic effects determined from epidemiological studies of exposed populations.
View Article and Find Full Text PDFSA J Radiol
October 2024
Department of Clinical Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein, South Africa.
Background: In CT, the volumetric CT dose index (CTDI), dose-length product (DLP) and patient's size-specific dose estimates (SSDE) are used as diagnostic reference level (DRL) metrics.
Objectives: To develop clinical local DRL values for CT chest-abdomen-pelvis (CAP) examinations using the CTDI, DLP and SSDE, and to determine the image quality achieved.
Method: In total, 201 cancer patients were included in the study.
Sci Rep
November 2024
Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
This study aimed to systematically evaluate the impact of a low-dose (LD) protocol using tube current reduction on image quality, the confidence for intervention planning and guidance, and diagnostic yield for computed tomography (CT) myelography. We retrospectively analyzed 68 patients who underwent CT myelography, with 34 investigations performed with a standard-dose (SD) and 34 investigations performed with a LD protocol (using tube current reduction). The different scans were matched considering variables such as sex, age, presence of spinal instrumentation, and body diameter.
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