AI Article Synopsis
- The study examined the clinicopathological features, immunohistochemistry, genotyping, and patient outcomes of gastrointestinal stromal tumor (GIST) patients in Inner Mongolia, China, over a five-year period.
- A total of 804 patients were analyzed, with findings indicating that GIST is most commonly found in the stomach and tends to affect middle-aged and older individuals, showing a predominance of high-risk cases.
- Results showed good long-term survival rates post-surgery, with 96.3% of high-risk patients surviving three years, highlighting the effectiveness of treatment and the need for ongoing monitoring of risk factors.
Article Abstract
Introduction: To analyze the clinicopathological characteristics, immunohistochemistry, genotyping and prognosis of patients in the multicenter GIST data in Inner Mongolia, China.
Methods: Retrospective analysis was performed on GIST data from January 2013 to January 2018 in Inner Mongolia. Descriptive statistics were used to analyze the clinical characteristics of GIST patients. The Chi-square test was performed on the modified NIH criteria by age distribution, and Kaplan-Merie method was used for survival analysis.
Results: A total of 804 patients were included in the GIST database in Inner Mongolia, with a male to female ratio of 1.1102:1. The most common location was the gastric (465). Mitotic count ≤5/50HPFs was found in 67.3 % patients. There were 276 patients with tumor diameter of 2-5 cm and 354 patients with tumor diameter of 5.1-10 cm.The modified NIH criteria was mainly of intermediate risk (210) and high risk (342). The recurrence and metastasis of patients were related to the tumor location, mitotic index, tumor size, and modified NIH criteria. All patients were followed up for 1-10 years, in which 63.1 % of them were followed up for at least three years. The 3-year survival rates of patients with modified NIH criteria of very low risk, low risk, intermediate risk, and high risk were 100 %, 100 %, 100 %, and 96.3 %, respectively.
Conclusions: The incidence of GIST in middle-aged and elder people in Inner Mongolia is high, and the long-term prognosis of patients after surgical treatment is good, which can objectively reflect the incidence, diagnosis and treatment of GIST in Inner Mongolia.
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| http://dx.doi.org/10.1016/j.asjsur.2021.07.040 | DOI Listing |
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