SARS-CoV-2 N gene mutations impact detection by clinical molecular diagnostics: reports in two cities in the United States.

Diagn Microbiol Infect Dis

New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene, New York, NY, USA. Electronic address:

Published: November 2021

Nasal and nasopharyngeal swab specimens tested by the Cepheid Xpert Xpress SARS-CoV-2 were analyzed by whole-genome sequencing based on impaired detection of the N2 target. Each viral genome had at least one mutation in the N gene, which likely arose independently in the New York City and Pittsburgh study sites.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255188PMC
http://dx.doi.org/10.1016/j.diagmicrobio.2021.115468DOI Listing

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