Objective: This study aimed to quantify the effect of the dwell time deviation constraint (DTDC) on brachytherapy treatment for cervical cancer.
Methods: A retrospective study was carried out on 20 patients with radical cervical cancer. The DTDC values changed from 0.0 to 1.0 by a step size of 0.2. We adjusted the optimization objectives to ensure that all plans were optimized to a high-risk clinical target volume (HRCTV) (the dose to 90% of the HRCTV) = 6 Gy, while keeping the dose to the organs at risk as low as possible. The dose-volume histogram parameters and the dwell time data were compared between plans with different DTDC values.
Results: The HRCTV volume covered by 150% of the prescription dose gradually increased with increasing DTDC values. As the DTDC value increased from 0.0 to 1.0, the effective dwell point proportion increased from 61.78% to 90.30%. The mean dwell time initially decreased with an increase in the DTDC value, reached the minimum value at DTDC = 0.8, then slightly increased at DTDC = 1.0.
Conclusions: When using inverse planning simulated annealing optimization for radical cervical cancer cases, the recommended DTDC value is approximately 0.6 if the organ dose needs to be limited.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385595 | PMC |
| http://dx.doi.org/10.1177/03000605211037477 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fracture Resistance of Chairside CAD/CAM Lithium Disilicate Partial and Full Coverage Crowns and Veneers for Maxillary Canines.
Oper Dent
January 2025
Nathaniel C Lawson, DDS, PhD, director of Master of Science in Dental Biomaterials program and associate professor, Department of Clinical and Community Sciences, University of Alabama at Birmingham School of Dentistry, Birmingham, AL, USA.
Objective: This study aimed to assess the fracture resistance of chairside computer assisted design and computer assisted manufacturing (CAD-CAM) lithium disilicate partial and full-coverage crowns and veneers for maxillary canines.
Methods And Materials: Forty-eight restorations for maxillary right canines (12 per group) were designed as follows: (1) partial crown with finish line in the upper middle third; (2) partial crown with finish line in the lower middle third; (3) traditional labial veneer; and (4) traditional full-coverage crown. Restorations were fabricated out of lithium disilicate (Amber Mill, Hassbio) using a chairside CAD-CAM system (Cerec Dentsply Sirona).
Radiofrequency Microneedling in Treating Primary Hyperhidrosis: A Systematic Review and Meta-Analysis.
Dermatol Surg
January 2025
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
Background: Radiofrequency microneedling (RFM) is a potential treatment for primary hyperhidrosis. However, its efficacy is unclear, and treatment parameters and outcomes vary across studies.
Objective: To understand the effect of RFM on treating primary hyperhidrosis, as measured by changes in the Hyperhidrosis Disease Severity Score (HDSS) before and after treatment, and to clearly define treatment settings most likely to optimize results.
Meta-Analysis of Pulsed-Field Ablation Versus- High-Power Short-Duration Ablation for Atrial Fibrillation.
Pacing Clin Electrophysiol
January 2025
Department of Pharmacy, First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Purpose: To optimize the effectiveness and safety of pulmonary vein isolation, pulsed-field ablation (PFA) and high-power short-duration ablation (HPSD) have recently been incorporated into clinical practice. The objective of this study is to conduct a comparative analysis, focusing on the efficacy, safety, and procedural efficiency of PFA and HPSD in the treatment of atrial fibrillation (AF).
Methods: A thorough search was performed across multiple databases to identify trials that compared PFA with HPSD for AF from their inception until July 2024.
Symbolic dynamics of joint brain states during dyadic coordination.
Chaos
January 2025
Department of Cognitive Sciences, University of California, Irvine, California 92617, USA.
We propose a novel approach to investigate the brain mechanisms that support coordination of behavior between individuals. Brain states in single individuals defined by the patterns of functional connectivity between brain regions are used to create joint symbolic representations of brain states in two or more individuals to investigate symbolic dynamics that are related to interactive behaviors. We apply this approach to electroencephalographic data from pairs of subjects engaged in two different modes of finger-tapping coordination tasks (synchronization and syncopation) under different interaction conditions (uncoupled, leader-follower, and mutual) to explore the neural mechanisms of multi-person motor coordination.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!