New classes of unexplored benzo[]thiolanes are synthesized from trisubstituted thioamides through copper-catalyzed intramolecular -arylation of thioamides for the first time. This method provides good to excellent yields with fully controlled chemoselectivity. Unusually, iminobenzo[]thiolanes are very stable under mild acidic conditions. A plausible mechanism is proposed for the chemoselective -arylation process.
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| http://dx.doi.org/10.1021/acsomega.1c03410 | DOI Listing |
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