Primary cutaneous cryptococcosis is an uncommon condition. Patients with immunosuppression and those of older age are more susceptible to infection, warranting investigations into underlying systemic disease. We report the case of a 49-year-old male with multiple sclerosis in remission on fingolimod who presented with a non-healing skin lesion on his upper thigh for a duration of two years. Skin biopsy showed dermal parasitized histiocytes, and serum antigens for histoplasmosis and were negative. Further investigation with polymerase chain reaction (PCR) demonstrated cutaneous cryptococcal infection, with no associated systemic signs or symptoms. This case report highlights an uncommon presentation of cutaneous cryptococcosis on an unexposed skin surface with successful and rapid improvement following fluconazole therapy without fingolimod discontinuation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367091 | PMC |
| http://dx.doi.org/10.7759/cureus.16444 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cutaneous cryptococcosis evaluation on reflectance confocal microscopy.
JAAD Case Rep
January 2025
Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York.
Deep Fungal Infections of Skin and Role of Histopathology in Diagnosis.
Indian J Dermatol
October 2024
Department of Dermatology, Institute of Child Health, Kolkata, India.
Introduction: Deep mycoses acquired by penetrating trauma to the skin can have varied and sometimes atypical morphological presentations resulting in diagnostic dilemmas and delay in treatment onset. Histopathology can be a useful tool in not only diagnosing but also differentiating various deep mycoses.
Aims And Objectives: To observe various morphological presentations and histopathological features of deep fungal infections.
Primary cutaneous cryptococcosis - History, concepts, clinical and therapeutic update.
An Bras Dermatol
January 2025
Department of Infectology, Dermatology, Diagnostic Imaging and Radiotherapy, Faculty of Medicine, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Cryptococcosis is a disease caused by fungi of the genus Cryptococcus, with the species Cryptococcus neoformans and Cryptococcus gattii being recognized as pathogenic. Cutaneous cryptococcosis can be classified as "secondary", developing from a previous systemic disease, or, on the contrary, "primary", resulting from transcutaneous inoculation of the agent. It can also be classified as "disseminated cutaneous cryptococcosis", when there is an associated systemic disease, or "localized", when it is restricted to the skin.
View Article and Find Full Text PDFFrom Histoplasmosis to Cryptococcosis: A diagnostic journey of pediatric scalp abscess.
Indian J Med Microbiol
December 2024
Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar, 751019, India. Electronic address:
Article Synopsis
- A 3-year-old boy undergoing treatment for disseminated tuberculosis developed scalp swelling, prompting a needle aspirate.
- The aspirate identified yeasts inside macrophages, initially misdiagnosed as Histoplasmosis but later confirmed as Cryptococcosis.
- Treatment with liposomal amphotericin B and fluconazole led to the resolution of lesions, marking this as a rare pediatric case of cryptococcosis from Odisha.
Concurrent Primary Cutaneous Cryptococcosis and Bowen's Disease in a Patient With Multiple Sclerosis on Fingolimod: A Rare Case Report and Review of Literature.
Cureus
October 2024
Department of Dermatology, Bezmialem Vakif University Faculty of Medicine, Istanbul, TUR.
Fingolimod is an oral disease-modifying treatment used for the relapsing-remitting forms of multiple sclerosis, which may render patients susceptible to opportunistic infections and lead to an increased risk of skin cancer. We report a 56-year-old woman with multiple sclerosis in remission on fingolimod treatment for five years presenting with the following skin lesions. Our patient presented with a non-healing ulcerated erythematous lesion on the left lower abdomen for six months and a crusted erythematous plaque on the forehead that had not healed for one year.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!