AI Article Synopsis
- Eales' disease is a retinal condition characterized by peripheral occlusive retinal phlebitis and is thought to involve an immunological disturbance, often linked to protein hypersensitivity.
- Three cases of Eales' disease were reported, all involving Caucasian men aged 27-58 who exhibited symptoms like vitreous hemorrhage and venous vasculitis, with positive tuberculin tests and IGRA results.
- Treatment for the patients included antituberculosis therapy, systemic steroids, retinal photocoagulation, and in some cases, intravitreal injections, highlighting the importance of early diagnosis and tailored therapies to prevent complications.
Article Abstract
Eales' disease is a peripheral occlusive retinal phlebitis, with an unclear pathogenesis. The classic association with hypersensitivity to protein infers that immunologic disturbance may be involved. Here, we described three cases of Eales' disease. All patients are Caucasian men aged 27-58 years and presented with vitreous hemorrhage and/or peripheral venous vasculitis. Tuberculin skin sensitive test ( screening test) and interferon-gamma release assay (IGRA) were positive in all patients. Therapeutic approach included antituberculosis therapy and systemic steroids, associated or not to immunosuppressive therapy, and retinal scatter photocoagulation in all cases. Antivascular endothelial grow factor () intravitreal injections were also required in two cases. Since various retinal diseases can resemble this presentation, Eales' disease is considered a diagnosis of exclusion. Early diagnosis and appropriate therapeutic approach are both essential to accomplish disease control and reduce ophthalmologic complications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371666 | PMC |
| http://dx.doi.org/10.1155/2021/1056659 | DOI Listing |
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