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http://dx.doi.org/10.3389/fgene.2021.735103 | DOI Listing |
Front Immunol
January 2025
Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, United States.
While durable antibody responses from long-lived plasma cell (LLPC) populations are important for protection against pathogens, LLPC may be harmful if they produce antibodies against self-proteins or self-nuclear antigens as occurs in autoimmune diseases such as systemic lupus erythematosus (SLE). Thus, the elimination of autoreactive LLPC may improve the treatment of antibody-driven autoimmune diseases. However, LLPC remain a challenging therapeutic target.
View Article and Find Full Text PDFFront Psychiatry
January 2025
School of Computer Science, Wuhan University, Wuhan, China.
Comput Struct Biotechnol J
January 2025
University of Cyprus, Department of Computer Science, Nicosia, Cyprus.
Protein Secondary Structure Prediction (PSSP) is regarded as a challenging task in bioinformatics, and numerous approaches to achieve a more accurate prediction have been proposed. Accurate PSSP can be instrumental in inferring protein tertiary structure and their functions. Machine Learning and in particular Deep Learning approaches show promising results for the PSSP problem.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Melanoma Institute Australia, Sydney, NSW 2065, Australia.
The field of translational bioinformatics is rapidly evolving, driving the convergence of molecular sciences and computational methods with their applications in industrial and clinical practice [...
View Article and Find Full Text PDFDiagnostics (Basel)
January 2025
Department of Musculoskeletal Radiology, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain.
We aimed to analyze potential predictors for the development of metachronous fractures (MFs) after osteoporotic vertebral fractures (OVFs), with particular focus on radiological variables obtained at initial X-rays and computed tomography (CT) examinations, treatment applied (conservative management [CM] versus percutaneous vertebroplasty [PV]), and fractures located at the thoracolumbar junction (T11-L2). We conducted a two-center, observational retrospective study, including patients with single-level OVFs treated with CM or VP. We collected socio-demographic, radiological and treatment-related variables.
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