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| http://dx.doi.org/10.3389/fnhum.2021.710905 | DOI Listing |
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Loneliness is associated with different structural brain changes in schizophrenia spectrum disorders and major depression.
Schizophr Res
January 2025
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Germany. Electronic address:
Background: Loneliness, distress from having fewer social contacts than desired, has been recognized as a significant public health crisis. Although a substantial body of research has established connections between loneliness and various forms of psychopathology, our understanding of the neural underpinnings of loneliness in schizophrenia spectrum disorders (SSD) and major depressive disorder (MDD) remains limited.
Methods: In this study, structural magnetic resonance imaging (sMRI) data were collected from 57 SSD and 45 MDD patients as well as 41 healthy controls (HC).
DAU-Net: a novel U-Net with dual attention for retinal vessel segmentation.
Biomed Phys Eng Express
January 2025
Faculty of Information Technology, Beijing University of Technology, Beijing, People's Republic of China.
In fundus images, precisely segmenting retinal blood vessels is important for diagnosing eye-related conditions, such as diabetic retinopathy and hypertensive retinopathy or other eye-related disorders. In this work, we propose an enhanced U-shaped network with dual-attention, named DAU-Net, divided into encoder and decoder parts. Wherein, we replace the traditional convolutional layers with ConvNeXt Block and SnakeConv Block to strengthen its recognition ability for different forms of blood vessels while lightweight the model.
View Article and Find Full Text PDFSignificance of birth in the maintenance of quiescent neural stem cells.
Sci Adv
January 2025
Department of Developmental and Regenerative Neurobiology, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
Birth is one of the most important life events for animals. However, its significance in the developmental process is not fully understood. Here, we found that birth-induced alteration of glutamine metabolism in radial glia (RG), the embryonic neural stem cells (NSCs), is required for the acquisition of quiescence and long-term maintenance of postnatal NSCs.
View Article and Find Full Text PDFRevisiting the in-plane and in-channel diffusion of lithium ions in a solid-state electrolyte at room temperature through neural network-assisted molecular dynamics simulations.
Phys Chem Chem Phys
January 2025
Guizhou Provincial Key Laboratory of Computing and Network Convergence, School of Information, Guizhou University of Finance and Economics, Guiyang, Guizhou 550025, P. R. China.
Developing superionic conductor (SIC) materials offers a promising pathway to achieving high ionic conductivity in solid-state electrolytes (SSEs). The LiGePS (LGPS) family has received significant attention due to its remarkable ionic conductivity among various SIC materials. molecular dynamics (AIMD) simulations have been extensively used to explore the diffusion behavior of Li ions in LiGePS.
View Article and Find Full Text PDFSynaptic-mitochondrial transport: mechanisms in neural adaptation and degeneration.
Mol Cell Biochem
January 2025
State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Synaptic plasticity is the basis for the proper functioning of the central nervous system. Synapses are the contact points between neurons and are crucial for information transmission, the structure and function of synapses change adaptively based on the different activities of neurons, thus affecting processes such as learning, memory, and neural development and repair. Synaptic activity requires a large amount of energy provided by mitochondria.
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