In the years 2019-2021, the Global Initiative for Asthma (GINA) recommended some fundamental changes in the management of patients with asthma, that also affect school children and adolescents. A very significant new recommendation is that for safety, short-acting β2-agonists (SABA) should now be given in combination with inhaled corticosteroids (ICS). In adolescents, GINA steps 1 and 2 are combined and a low-dose ICS formoterol combination as needed is recommended for asthma problems. Alternatively, separation into step 1, with inhalation of SABA and an ICS as needed, and step 2, with daily inhalation of an ICS and SABA as needed, as before, is recommended. This path is suggested as the preferred treatment in children aged 6-11 years. However, these recommendations have not been adopted by all national and international guidelines, because the evidence is weak, especially in children. Tiotropium, mepolizumab, and dupilumab were added to the therapy for severe asthma.Children with asthma do not become ill with COVD-19 more often or more severely than children without asthma. Various mechanisms, such as a possible protective effect of type 2 inflammation, the antiviral and immunomodulatory effects of ICS, and the downregulation of ACE2 receptors by allergic sensitization could be responsible for this.
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http://dx.doi.org/10.1007/s00608-021-00908-3 | DOI Listing |
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January 2025
Wayne State University School of Medicine, Detroit, MI, USA.
Hospital mergers have increased significantly since 2010, driven by factors such as healthcare policy changes, reimbursement, economies of scale, and quality improvement goals. However, limited evidence exists about how these mergers affect the quality of care and cancer outcomes. We conducted a difference-in-differences analysis to assess the impact of hospital consolidation on cancer outcomes.
View Article and Find Full Text PDFFront Psychiatry
January 2025
Department of Medical Insurance and Price, Dongguan First Hospital Affiliated to Guangdong Medical University, Dongguan, Guangdong, China.
Objective: Long-term care needs have grown with population aging. This study explores the relationships among health status, healthcare expenditure, and long-term care insurance (LTCI) among the older adults.
Methods: Using data from the China Health and Retirement Longitudinal Study (CHARLS 2011, 2013, 2015, 2018, and 2020) and based on the demand model for healthcare services, this study employed the difference-in-difference (DID) method to assess how the implementation of LTCI contributed to the health status and healthcare expenditures of the older adults.
Front Endocrinol (Lausanne)
January 2025
Department of Traditional Chinese Medicine, Zigong First People's Hospital, Zigong, Sichuan, China.
Background: The effects of resveratrol supplementation on inflammation and oxidative stress in patients with type 2 diabetes mellitus (T2DM) were controversial. A meta-analysis was performed to assess the changes in levels of inflammation and oxidative stress in patients with T2DM.
Methods: Relevant literatures before November 6, 2024 were screened through Web of Science,Embase,the Cochrane Library and other sources (ClinicalTrials, ProQuest Dissertations and Theses).
Background: In high-burden settings, most tuberculosis (TB) transmission likely occurs outside the home. Our qualitative study in Zambia explored the acceptability and preferences for designing TB active case finding (ACF) strategies to reach non-household contacts of people with TB.
Methods: We conducted 56 in-depth interviews with persons with TB ( = 12), TB healthcare workers (HCWs) ( = 10), TB lay HCWs ( = 10), and leaders/owners ( = 12) and attendees ( = 12) of community venue types identified as potential TB transmission locations.
Front Health Serv
January 2025
Family Medicine Department, Georgetown University School of Medicine, Washington, DC, United States.
Introduction: Adults over the age of 65 are at a higher risk for diagnostic errors due to a myriad of reasons. In primary care settings, a large contributor of diagnostic errors are breakdowns in information gathering and synthesis throughout the patient-provider encounter. Diagnostic communication interventions, such as the Agency for Healthcare Research and Quality's "Be the Expert on You" note sheet, may require adaptations to address older adults' unique needs.
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