A new mechanism of leptin extravasation from the bloodstream into the brain may have been discovered. According to recent findings by Butiaeva et al., pericytes within the blood-brain barrier (BBB) express the leptin receptor and, upon activation, facilitate the movement of the appetite-suppressing hormone into deeper regions of the hypothalamus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764624 | PMC |
| http://dx.doi.org/10.1016/j.tem.2021.08.001 | DOI Listing |
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