To investigate the influence of epileptogenic cortex (Rolandic areas) with executive functions in Rolandic epilepsy using structural covariance analysis of structural magnetic resonance imaging (MRI). Structural MRI data of drug-naive patients with Rolandic epilepsy (n = 70) and typically developing children as healthy controls (n = 83) were analyzed using voxel-based morphometry. Gray matter volumes in the patients were compared with those of healthy controls, and were further correlated with epilepsy duration and cognitive score of executive function, respectively. By applying Granger causal analysis to the sequenced morphometric data according to disease progression information, causal network of structural covariance was constructed to assess the causal influence of structural changes from Rolandic cortices to the regions engaging executive function in the patients. Compared with healthy controls, epilepsy patients showed increased gray matter volume in the Rolandic regions, and also the regions engaging in executive function. Covariance network analyses showed that along with disease progression, the Rolandic regions imposed positive causal influence on the regions engaging in executive function. In the patients with Rolandic epilepsy, epileptogenic regions have causal influence on the structural changes in the regions of executive function, implicating damaging effects of Rolandic epilepsy on human brain.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11682-021-00517-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of Sleep Spindle Rate With Memory Consolidation in Children With Rolandic Epilepsy.
Neurology
January 2025
Department of Neurology, Massachusetts General Hospital, Boston.
Background And Objectives: Rolandic epilepsy (RE), the most common childhood focal epilepsy syndrome, is characterized by a transient period of sleep-activated epileptiform activity in the centrotemporal regions and variable cognitive deficits. Sleep spindles are prominent thalamocortical brain oscillations during sleep that have been mechanistically linked to sleep-dependent memory consolidation in animal models and healthy controls. Sleep spindles are decreased in RE and related sleep-activated epileptic encephalopathies.
View Article and Find Full Text PDFIndependent component analysis of brain network in drug-resistant epilepsy patients with vagus nerve stimulators.
Int J Neurosci
January 2025
Department of Functional Neurosurgery, Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- The study aimed to analyze the changes in brain network activity, specifically the default mode network (DMN), frontoparietal network (FPN), and cerebellar network (CN), in patients with drug-resistant epilepsy (DRE) after they received vagus nerve stimulation (VNS).
- Fifteen patients underwent resting-state fMRI scans, with the data analyzed to compare brain activity before and after VNS, revealing both increases and decreases in various brain regions associated with DMN, FPN, and CN.
- The findings indicate that VNS leads to distinct activity changes in the brain networks related to sensorimotor, language, memory, and emotion, but the differences in activity in the
Unraveling the Diffusion MRI-Based Glymphatic System Alterations in Children with Rolandic Epilepsy.
Acad Radiol
November 2024
Department of Radiology, Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Engineering Research Center of Intelligent Medical Imaging in Guizhou Higher Education Institutions, Zunyi 563003, China (M.M., F.W., X.L., H.Y., H.L.). Electronic address:
Rationale And Objectives: Although dysfunction of the glymphatic system in adult epilepsy has been extensively studied, there is a lack of research on the changes in this system during childhood development, particularly in children with Rolandic epilepsy (RE). This study aimed to investigate the changes in diffusion MRI measures related to the glymphatic function in children with RE.
Materials And Methods: A total of thirty-eight children with RE and thirty-six demographically matched healthy children were enrolled in the study.
Combination of magnetoencephalographic and clinical features to identify atypical self-limited epilepsy with centrotemporal spikes.
Epilepsy Behav
December 2024
Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, 210029 Jiangsu, China. Electronic address:
Introduction: Our aim was to use magnetoencephalography (MEG) and clinical features to early identify self-limited epilepsy with centrotemporal spikes (SeLECTS) patients who evolve into atypical SeLECTS (AS).
Methods: The baseline clinical and MEG data of 28 AS and 33 typical SeLECTS (TS) patients were collected. Based on the triple-network model, MEG analysis included power spectral density representing spectral power and corrected amplitude envelope correlation representing functional connectivity (FC).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!