X-ray micro-tomography based analysis of porous hydrogel has gained a wide attention recently. It provides an advantage in three-dimensional analysis of pore morphometric and interconnection within the hydrogel network. We have fabricated highly elastic graphene crosslinked collagen hydrogel using cryogelation technique. The influence of graphene as a nano-crosslinker on the overall porosity and inter-connections between the pores in collagen cryogels was determined using X-ray micro-tomography. We have evaluated the effect of different concentration of amino-functionalized graphene nano-crosslinker on collagen cryogels porosity, pore volume, interconnectivity density, fractal dimensions and pore wall thickness. This study, reveals that the use of graphene as a nano-crosslinker have improved micro-architecture as compare to collagen cryogels in the absence of graphene for tissue engineering applications.
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| http://dx.doi.org/10.1016/j.micron.2021.103127 | DOI Listing |
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