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Synthesis of photo-responsive κ-carrageenan-based hydrogels for drug delivery application.
Int J Biol Macromol
December 2024
Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Natural polymer-based hydrogels may act as versatile platforms in controlled drug delivery. In this regard, photoactive κ-carrageenan (κ-Crg) hydrogels modified with cinnamate (CN) groups are developed for pH-sensitive release of drugs. κ-Crg-CN derivatives containing 17 %, 33 %, and 49 % cinnamate contents, named κ-Crg-CN1, κ-Crg-CN2, and κ-Crg-CN3, respectively, are prepared and cross-linked by UV-induced [2π + 2π] cycloaddition.
View Article and Find Full Text PDF"3D channel maze" to control drug release from multiple unit tablets.
J Control Release
December 2024
Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China; Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:
Diffusion is defined as general mechanism for drug release from advanced delivery systems, yet dynamic structure of dosage form intrinsically plays an unknown role. The synchrotron radiation X-ray micro-computed tomography (SR-μCT) three-dimensional (3D) imaging and in-depth analysis of 3D structures were applied to readily differentiate materials and accurately capture internal structure changes of multiple unit pellet system (MUPS) and the constituent pellets, visualizing internal 3D structure of a MUPS of theophylline tablets for their 3 levels hierarchy structures: pellets with rapid drug release characteristics, a protective cushion layer and a matrix layer. Drug release pathways were extracted from SR-μCT images and a 3D maze network was constructed using pore network analysis to quantify the internal structural evolution during drug release.
View Article and Find Full Text PDFExperimental and modeling approaches to determine drug diffusion coefficients in artificial mucus.
Heliyon
October 2024
Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, AR, 72701, USA.
Article Synopsis
- Asthma causes inflammation and mucus buildup in the lungs, impacting airflow and making it difficult for orally or inhaled drugs to work effectively.
- This study tested the diffusion of two asthma medications, theophylline and albuterol, through an artificial mucus layer, measuring their concentration over time using special spectroscopy techniques.
- The results yielded diffusion coefficients for the drugs, which matched previous studies, and demonstrated a novel, non-invasive method to evaluate how well drugs can penetrate through complex mucus conditions.
From Cellulose Solutions to Aerogels and Xerogels: Controlling Properties for Drug Delivery.
Biomacromolecules
November 2024
Mines Paris, PSL University, Center for Materials Forming (CEMEF), UMR CNRS 7635, CS 10207, 06904 Sophia Antipolis, France.
A cheap and easy-to-recycle solvent, namely, aqueous NaOH with no additives, was used to dissolve cellulose and make cross-linker-free materials with varying porosity, testing them as drug delivery devices. Cellulose solutions were gelled, coagulated in a nonsolvent (water, ethanol), and dried either using supercritical CO (aerogels) or low-vacuum evaporation (named "xerogels"). Aerogels had densities of around 0.
View Article and Find Full Text PDFDesign and Evaluation of New Gel-Based Floating Matrix Tablets Utilizing the Sublimation Technique for Gastroretentive Drug Delivery.
Gels
September 2024
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand.
A gel-based floating matrix tablet was formulated and evaluated using the sublimation technique to enhance gastroretentive drug delivery. Anhydrous theophylline was employed as the active pharmaceutical ingredient, combined with sublimation agents and hydroxypropyl methylcellulose as the gel-forming polymer. The resulting tablets exhibited high porosity, immediate floatation, and sustained buoyancy for over 8 h.
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