Emerging concepts and opportunities for endocrine disruptor screening of the non-EATS modalities.

Environ Res

Division of Experimental Medicine, School of Medicine, Faculty of Medicine and Biomedical Sciences, McGill University, 850 Sherbrooke Street, Montréal, Québec, H3A 1A2, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Chemin Cote Ste Catherine, Montréal, Québec, H3T 1E2, Canada.

Published: March 2022

Endocrine disrupting chemicals (EDCs) are ubiquitous in the environment and involve diverse chemical-receptor interactions that can perturb hormone signaling. The Organization for Economic Co-operation and Development has validated several EDC-receptor bioassays to detect endocrine active chemicals and has established guidelines for regulatory testing of EDCs. Focus on testing over the past decade has been initially directed to EATS modalities (estrogen, androgen, thyroid, and steroidogenesis) and validated tests for chemicals that exert effects through non-EATS modalities are less established. Due to recognition that EDCs are vast in their mechanisms of action, novel bioassays are needed to capture the full scope of activity. Here, we highlight the need for validated assays that detect non-EATS modalities and discuss major international efforts underway to develop such tools for regulatory purposes, focusing on non-EATS modalities of high concern (i.e., retinoic acid, aryl hydrocarbon receptor, peroxisome proliferator-activated receptor, and glucocorticoid signaling). Two case studies are presented with strong evidence amongst animals and human studies for non-EATS disruption and associations with wildlife and human disease. This includes metabolic syndrome and insulin signaling (case study 1) and chemicals that impact the cardiovascular system (case study 2). This is relevant as obesity and cardiovascular disease represent two of the most significant health-related crises of our time. Lastly, emerging topics related to EDCs are discussed, including recognition of crosstalk between the EATS and non-EATS axis, complex mixtures containing a variety of EDCs, adverse outcome pathways for chemicals acting through non-EATS mechanisms, and novel models for testing chemicals. Recommendations and considerations for evaluating non-EATS modalities are proposed. Moving forward, improved understanding of the non-EATS modalities will lead to integrated testing strategies that can be used in regulatory bodies to protect environmental, animal, and human health from harmful environmental chemicals.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669078PMC
http://dx.doi.org/10.1016/j.envres.2021.111904DOI Listing

Publication Analysis

Top Keywords

non-eats modalities
24
non-eats
9
signaling case
8
case study
8
modalities
7
chemicals
7
edcs
5
emerging concepts
4
concepts opportunities
4
opportunities endocrine
4

Similar Publications

Environmental variation in the Anthropocene involves several factors that interfere with endocrine systems of wildlife and humans, presenting a planetary boundary of still unknown dimensions. Here, we focus on chemical compounds and other impacts of anthropogenic and natural origins that are adversely affecting reproduction and development. The main sink of these endocrine disruptors (EDs) is surface waters, where they mostly endanger aquatic vertebrates, like teleost fish and amphibians.

View Article and Find Full Text PDF

Emerging concepts and opportunities for endocrine disruptor screening of the non-EATS modalities.

Environ Res

March 2022

Division of Experimental Medicine, School of Medicine, Faculty of Medicine and Biomedical Sciences, McGill University, 850 Sherbrooke Street, Montréal, Québec, H3A 1A2, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Chemin Cote Ste Catherine, Montréal, Québec, H3T 1E2, Canada.

Endocrine disrupting chemicals (EDCs) are ubiquitous in the environment and involve diverse chemical-receptor interactions that can perturb hormone signaling. The Organization for Economic Co-operation and Development has validated several EDC-receptor bioassays to detect endocrine active chemicals and has established guidelines for regulatory testing of EDCs. Focus on testing over the past decade has been initially directed to EATS modalities (estrogen, androgen, thyroid, and steroidogenesis) and validated tests for chemicals that exert effects through non-EATS modalities are less established.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!