AI Article Synopsis
- Methyl gallate shows promising anti-glycation effects, which may help in reducing skin aging caused by advanced glycation end products (AGEs).
- In studies, methyl gallate effectively inhibited glycation in both lab settings and human skin samples, promoting healthier skin structure and protein expression.
- The safety tests indicated that methyl gallate is non-irritating to human skin, suggesting its potential as a cosmetic ingredient for anti-aging products.
Article Abstract
Background: The build-up of advanced glycation end products (AGEs) is one of important factor of skin aging. Natural compounds with anti-glycation activities might have great anti-aging potential.
Aims: The objective of this study was to evaluate an anti-glycation effects of methyl gallate as a potent ingredient for anti-aging.
Methods: We first evaluated the AGEs inhibitory ability of methyl gallate in BSA/glucose system. Levels of Nε-CML and carbonyl contents were also measured in BSA/glucose system. To further investigate if methyl gallate could prevent glycation in full-thickness human skin explants. Glycation action was determined by the observation of the general morphology of dermis and epidermis structures and FBN-1 and of CML immunostaining. In an in-vivo study, primary irritation test was also performed to ensure the safety of methyl gallate for human skin.
Results: It is known that methyl gallate can suppress glycation reaction between BSA and glucose. Methyl gallate also has a remarkable potential to reduce the oxidation of proteins. Furthermore, the anti-glycation activity of methyl gallate has been confirmed in a human skin ex-vivo model. Methyl gallate decreased the expression of CML but stimulated the expression of FBN-1 compared with MGO treatment. In an in-vivo study, methyl gallate (0.1%) did not cause any skin irritation, suggesting that methyl gallate could be used as an active ingredient in cosmetics.
Conclusion: Our results showed that methyl gallate could protect against glucose-mediated glycation in vitro. Furthermore, methyl gallate significantly prevented glycation in living human skin explants. Due to these beneficial effects, methyl gallate can be used to prevent or manage AGE-mediated skin aging.
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| http://dx.doi.org/10.1111/jocd.14406 | DOI Listing |
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