AI Article Synopsis
- * A total of 477 patients participated, with a mean age of 42.4 years, and 15.3% had a history of typhoid fever; however, no Salmonella typhi or paratyphi were detected in the cultures or PCR tests.
- * The study suggests that future research should focus on screening individuals with gall bladder diseases to potentially improve the detection of S. typhi carriers using culture and PCR methods.
Article Abstract
We aimed to detect typhoid carriers by performing duodenal fluid culture in patients in a tertiary care hospital in Pakistan. A cross-sectional study was conducted during 2017 at the Aga Khan University Hospital, Karachi. Patients who underwent upper gastrointestinal endoscopy were included. Participants were interviewed, and duodenal fluid samples were taken for culture to detect Salmonella typhi (S. typhi) and paratyphi. A polymerase chain reaction on 100 randomly selected sub-samples was also conducted. A total of 477 participants were enrolled. The mean age was 42.4±15.5 years. History of typhoid fever was present in 73 (15.3%) participants. Out of the 477 duodenal fluid cultures tested for various micro-organisms, 250 (52.4%) were positive. Neither S. typhi nor paratyphi were isolated. S. typhi was also not detected by PCR. To better detect S. typhi carriage in general population, future studies should target people with gall bladder diseases and screen them using culture and PCR based methods.
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| http://dx.doi.org/10.47391/JPMA.580 | DOI Listing |
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