AI Article Synopsis
- This study examined the relationship between serum levels of GDF11 and BMP4 and lumbar spine bone mineral density (LBMD) in postmenopausal Chinese women.
- The research involved 350 women with an average age of about 63, using dual-energy X-ray absorptiometry to measure LBMD and enzyme immunoassays for serum levels.
- Results indicated that higher GDF11 levels were positively associated with LBMD and inversely related to osteoporosis, while BMP4 showed no significant relationship with either LBMD or osteoporosis.
Article Abstract
Purpose: The relationship between transforming growth factor β superfamily members (GDF11 and BMP4) and bone metabolism remains controversial. The aim of this study was to investigate the association between serum GDF11 and BMP4 levels and lumbar spine bone mineral density (LBMD) in a cohort of postmenopausal Chinese women.
Methods: This was a non-prospective cross-sectional study of 350 postmenopausal women with a mean age of 63.13 ± 8.66 years who came from Shenyang, China. LBMD was measured using dual-energy X-ray absorptiometry. Serum GDF11 and BMP4 concentrations were detected using a sandwich enzyme immunoassay kit. Pearson's correlation analysis and regression analyses were carried out to investigate the relationships between LBMD and serum GDF11 and BMP4 levels.
Results: A linear association between LBMD and serum LgGDF11 concentration was observed after adjusting for numerous confounders (P = 0.018). In addition, the osteoporosis (OP) was inversely related to LgGDF11 and the odds ratios for postmenopausal women with lumbar OP in LgGDF11 quartile group 2, group 3, and group 4 were 0.46 (95% CI 0.23-0.90, P < 0.05), 0.41 (95% CI 0.20-0.84, P < 0.05), and 0.30 (95% CI 0.14-0.63, P < 0.01), respectively (P = 0.001 for the trend), when compared to the highest quartile of LgGDF11 after adjustments for many confounding variables in this study.
Conclusions: This study showed that serum GDF11 levels were linearly related to LBMD, and it was also revealed that serum GDF11 levels were significantly associated with lumbar OP in postmenopausal women. However, serum BMP4 levels were not associated with LBMD and lumbar OP.
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| http://dx.doi.org/10.1007/s00404-021-06183-8 | DOI Listing |
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Article Synopsis
- This study examined the relationship between serum levels of GDF11 and BMP4 and lumbar spine bone mineral density (LBMD) in postmenopausal Chinese women.
- The research involved 350 women with an average age of about 63, using dual-energy X-ray absorptiometry to measure LBMD and enzyme immunoassays for serum levels.
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