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| http://dx.doi.org/10.1038/s41396-021-01090-x | DOI Listing |
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Targeted dual-receptor phage cocktail against : insights into phage-host interactions and resistance mechanisms.
Front Microbiol
December 2024
Department of Food and Animal Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.
Introduction: is a notorious foodborne pathogen, frequently contaminating powdered infant formula and causing life-threatening diseases in infants. The escalating emergence of antibiotics-resistant mutants has led to increased interest in using bacteriophage as an alternative antimicrobial agent.
Methods: Two phages, CR8 and S13, were isolated from feces and soil samples and their morphology, physiology, and genomics were characterized.
Virome assembly reveals draft genomes of native Pseudomonas phages isolated from a paediatric bronchoalveolar lavage sample.
Microbiol Resour Announc
December 2024
Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth, Western Australia, Australia.
We present lung virome data recovered through shotgun metagenomics in bronchoalveolar lavage fluid from an infant with cystic fibrosis, who tested positive for infection. Using a bioinformatic pipeline for virus characterization in shotgun metagenomic data, we identified five viral contigs representing Pseudomonas phages classified as Caudoviricetes.
View Article and Find Full Text PDFA metagenome-assembled genome inventory for children reveals early-life gut bacteriome and virome dynamics.
Cell Host Microbe
December 2024
Microbiota I-Center (MagIC), Hong Kong SAR 999077, China; Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR 999077, China; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR 999077, China. Electronic address:
Existing microbiota databases are biased toward adult samples, hampering accurate profiling of the infant gut microbiome. Here, we generated a metagenome-assembled genome inventory for children (MAGIC) from a large collection of bulk and viral-like particle-enriched metagenomes from 0 to 7 years of age, encompassing 3,299 prokaryotic and 139,624 viral species-level genomes, 8.5% and 63.
View Article and Find Full Text PDFBronchoscopy in children with diffuse alveolar hemorrhage under general anesthesia with spontaneous respiration by face mask ventilation.
Medicine (Baltimore)
November 2024
Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
To improve the management level of general anesthesia during bronchoscopy in the children with diffuse alveolar hemorrhage (DAH). A retrospective study was conducted in the children with DAH who had performed bronchoscopy under general anesthesia with spontaneous respiration by face mask ventilation initially from June 2021 to June 2022 in our hospital. (1) Thirty-four children who had underwent 38 bronchoscopy procedures were included.
View Article and Find Full Text PDFImpact of Sublethal Disinfectant Exposure on Antibiotic Resistance Patterns of Pseudomonasaeruginosa.
Med Princ Pract
November 2024
Department of Medical Laboratory Technology, Al-Qalam University College, Kirkuk, Iraq.
Article Synopsis
- Hospital disinfectants at low concentrations can promote bacterial survival and resistance, as seen in a study with Pseudomonas aeruginosa strains isolated from infants.
- Exposure to these disinfectants resulted in a notable percentage of strains developing resistance, while some strains became sensitive to certain antibiotics after initial resistance.
- The findings highlight the risk of improper disinfectant use, potentially leading to new antibiotic-resistant bacteria in healthcare settings, which could complicate infection control measures.
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