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Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach.
Pharmaceutics
January 2025
Department of Pharmaceutical Biology, Faculty of Pharmacy, Padjadjaran University, Sumedang 45363, Indonesia.
The deposition of monosodium urate (MSU) crystals within joint spaces produces a painful inflammatory condition known as gout, a specific form of arthritis. The condition calls for a combined curative and preventive management model. A new development in the approach to gout is that of NLRP3-targeted biologic agents, such as monoclonal therapies, to provide more accurate treatment by blocking specific pro-inflammatory cytokines.
View Article and Find Full Text PDFReal-Time Prediction of the Yarn Break Position Using Vibration Measurement.
Sensors (Basel)
January 2025
Institute of Automatic Control, Lodz University of Technology, 90-537 Lodz, Poland.
Warping is a crucial process that connects two main stages of production: yarn manufacturing and fabric creation. Two interrelated parameters affect the efficiency of this technological process: warping speed and the ability to swiftly detect the yarn breaks caused by various defects. The faster a break is detected and the warping machine stopped, the higher the machine's working speed can be.
View Article and Find Full Text PDFUnveiling the future: Wavelet- ARIMAX analysis of climate and diarrhea dynamics in Bangladesh's Urban centers.
BMC Public Health
January 2025
School of Business, University of Southern Queensland, Queensland (QLD), 4350, Australia.
Background: Diarrheal infections continue to be a major public health concern in Bangladesh, especially in urban areas where population density and environmental variables increase dissemination risks. Identifying the intricate connections between weather variables and diarrhea epidemics is critical for developing effective public health remedies.
Methods: We deploy the novel approach of Wavelet-Autoregressive Integrated Moving Average with Exogenous Variable (WARIMAX) and the traditional Autoregressive Integrated Moving Average with Exogenous Variable (ARIMAX) technique to forecast the incidence of diarrhea by analyzing the influence of climate factors.
Quantum-enhanced time-domain spectroscopy.
Sci Adv
January 2025
James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UK.
The time-resolved detection of mid- to far-infrared electric fields absorbed and emitted by molecules is among the most sensitive spectroscopic approaches and has the potential to transform sensing in fields such as security screening, quality control, and medical diagnostics. However, the sensitivity of the standard detection approach, which relies on encoding the far-infrared electric field into amplitude modulation of a visible or near-infrared probe laser pulse, is limited by the shot noise of the latter. This constraint cannot be overcome without using a quantum resource.
View Article and Find Full Text PDFStudy on the evolution of the spatial patterns and driving factors of national agricultural cultural heritage in China.
PLoS One
January 2025
College of Tourism, Hubei University, Wuhan, Hubei, China.
The study analyzed the spatial distribution characteristics, evolution rules, and driving factors of 138 China's national agricultural cultural heritage sites from 2013 to 2021 at the overall and regional levels, using kernel density analysis, Centres for standard deviation ellipse analyses, spatial autocorrelation analysis, and geographical detector analysis.The results showed that: ①From an overall perspective, the spatial pattern of China's national agricultural cultural heritage changed greatly from 2013 to 2021, with a highly uneven spatial distribution, gradually showing a distribution pattern of "widely distributed, locally concentrated". The spatial distribution of China's national agricultural cultural heritage is increasingly evident, and the spatial distribution type has evolved from discrete to clustered.
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