Growing evidence implicates a vital role for TPC2/Ca signaling in pathophysiological processes attributed to cancer, raising questions regarding the utility of TPC2 as a cancer therapeutic target. In this issue of Cell Chemical Biology, Müller et al. (2021) develop TPC2 inhibitors, SG005 and SG-094, exhibiting anti-tumor effects with potential translational relevance.
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| http://dx.doi.org/10.1016/j.chembiol.2021.07.020 | DOI Listing |
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