AI Article Synopsis
- Small peptides that bind specifically to CD8+ T cells show promise for diagnosing immune responses through molecular imaging.
- Researchers developed F-labeled peptides targeting human CD8α using a fast and efficient chemical process, achieving high radiochemical yield.
- The inclusion of a hydrophilic linker enhances the tracer's pharmacokinetics and improves image quality in PET imaging studies.
Article Abstract
Chemically synthesized, small peptides that bind with high affinity and specificity to CD8-expressing (CD8+) tumor-infiltrating T cells, yet retain the desirable characteristics of small molecules, hold valuable potential for diagnostic molecular imaging of immune response. Here, we report the development of F-labeled peptides targeting human CD8α with nanomolar affinity via the strain-promoted sydnone-alkyne cycloaddition with 4-[F]fluorophenyl sydnone. The F-sydnone is produced in one step, in high radiochemical yield, and the peptide labeling proceeds rapidly. A hydrophilic chemical linker results in a tracer with favorable pharmacokinetic properties and improved image contrast, as demonstrated by PET imaging studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.bioconjchem.1c00379 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!