AI Article Synopsis
- - Pancreatic and biliary duct cancers are leading causes of acute cholangitis (AC), prompting a study comparing cancer-associated cholangitis (CAC) in 81 patients to non-cancer-associated cholangitis (NCAC) in 49 patients.
- - While both groups showed similar clinical and biological features, CAC had higher rates of antibiotic resistance, more frequent need for multiple biliary drainages, and increased mortality at 28 days compared to NCAC.
- - The study suggests that cholangitis linked to pancreatic or biliary cancers requires tailored antibiotic treatment and that early biliary drainage could enhance patient outcomes.
Article Abstract
Pancreatic and biliary duct cancers are increasing causes of acute cholangitis (AC). We retrospectively characterize 81 cancer-associated cholangitis (CAC) compared to 49 non-cancer-associated cholangitis (NCAC). Clinical and biological presentations were similar. However, in CAC, antibiotic resistance and inadequate empirical antibiotic therapy were more frequent; more patients required ≥ 2 biliary drainages; and mortality at day 28 was higher than in NCAC. Death was associated with initial severity and CAC in a multivariate analysis. Cholangitis associated with pancreatic or biliary duct cancers requires specific empirical antimicrobial therapy; early use of biliary drainage may improve outcomes.
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| http://dx.doi.org/10.1007/s10096-021-04289-0 | DOI Listing |
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