During the systematic screening of bioactive compounds from our marine natural product library, crude extract of the marine-derived fungus strain MF029 exhibited moderate bioactivities against , S, methicillin-resistant , and bacillus Calmette-Guérin (BCG). Further chemical investigation resulted in the identification of two new compounds, chaetominine A () and sphingofungin I (), together with four known compounds, emodin (), chaetominine (), sphingofungin D () and trypacidin (). Trypacidin displayed potential antitubercular activity with MIC value of 1.25 μg/mL.
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| http://dx.doi.org/10.1080/14786419.2019.1660331 | DOI Listing |
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