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Enantioselective determination of phenthoate enantiomers in plant-origin matrices using reversed-phase high-performance liquid chromatography-tandem mass spectrometry. | LitMetric

AI Article Synopsis

  • Phenthoate, a chiral organophosphate pesticide, has two enantiomers that vary in toxicity and effectiveness, necessitating selective detection methods due to its harmful effects on human health.
  • The study developed a fast and effective method using reversed-phase high-performance liquid chromatography-tandem mass spectrometry to separate and detect these enantiomers specifically in fruits, vegetables, and grains within just 9 minutes.
  • Results showed the detection method had high sensitivity, linearity, and satisfactory recovery rates, and a field trial revealed that one enantiomer, (-)-phenthoate, degrades faster than the other, leading to increased levels of the less toxic (+)-phenthoate.

Article Abstract

Phenthoate is a chiral organophosphate pesticide with a pair of enantiomers which differ in toxicity, behavior and insecticidal activity, and its acute toxicity on human health owing to the inhibition of acetylcholinesterase highlights the need for enantioselective detection of enantiomers. Therefore, this study aimed to establish a simple rapid method for separation and detection of phenthoate enantiomers in fruits, vegetables and grains. The enantiomers were separated using reversed-phase high-performance liquid chromatography-tandem mass spectrometry for the first time. Rapid chiral separation (within 9 min) of the target compound was achieved on a chiral OJ-RH column with the mobile phase of methanol-water = 85:15(v/v), at a flow rate of 1 ml/min and a column temperature of 30°C. Acetonitrile and graphitized carbon black were used as the extractant and sorbent for pretreatment, respectively. This method provides excellent linearity (correlation coefficient ≥0.9986), high sensitivity (limit of quantification 5 μg/kg and limit of detection <0.25 μg/kg), satisfactory mean recoveries (76.2-91.0%) and relative standard deviation (intra-day RSDs ranged from 2.0 to 7.9% and inter-day RSDs ranged from 2.4 to 8.4%). In addition, a field trial to explore the stereoselective degradation of phenthoate enantiomers in citrus showed that (-)-phenthoate degraded faster than its antipode, resulting in the relative accumulation of (+)-phenthoate.

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Source
http://dx.doi.org/10.1002/bmc.5229DOI Listing

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